肉毒梭菌 C 型和 D 型类毒素疫苗对丹麦奶牛的效力。
Efficacy of Clostridium botulinum types C and D toxoid vaccination in Danish cows.
机构信息
Institute of Bacteriology and Mycology, Faculty of Veterinary Medicine, University of Leipzig, An den Tierkliniken 29, D-04103 Leipzig, Germany.
出版信息
Anaerobe. 2013 Oct;23:97-101. doi: 10.1016/j.anaerobe.2013.06.011. Epub 2013 Jul 4.
In the present study the efficacy Botulism vaccine (formalinised aluminum hydroxide gel adsorbed toxoid of Clostridium botulinum types C and D) was evaluated in four Danish dairy cows under field conditions. Other four dairy herds were unvaccinated. Blood serum of all animals was analyzed for specific C. botulinum types A, B, C, D and E antibodies using a developed ELISA. Feces of all animals were analyzed for botulinum neurotoxins (BoNTs) and C. botulinum spores. C. botulinum types C and D antibodies were significantly (p < 0.05) increased in vaccinated animals. Vaccination with botulism vaccine significantly reduced (p < 0.001) BoNTs and C. botulinum spores in cattle feces. Our findings represent that C. botulinum vaccination increases specific blood serum antibodies and reduces free BoNTs and C. botulinum spores in feces.
在本研究中，在现场条件下评估了 Botulism 疫苗（经甲醛化的氢氧化铝凝胶吸附的 Clostridium botulinum 类型 C 和 D 类毒素）在 4 头丹麦奶牛中的功效。其他 4 个奶牛群未接种疫苗。使用开发的 ELISA 分析所有动物的血清中针对特定的 C. botulinum 类型 A、B、C、D 和 E 抗体。分析所有动物的粪便中是否存在肉毒神经毒素 (BoNTs) 和 C. botulinum 孢子。接种疫苗的动物中 C. botulinum 类型 C 和 D 抗体显著增加（p<0.05）。接种肉毒杆菌疫苗可显著降低（p<0.001）牛粪便中的 BoNTs 和 C. botulinum 孢子。我们的研究结果表明，C. botulinum 疫苗接种可增加特异性血清抗体，并减少粪便中的游离 BoNTs 和 C. botulinum 孢子。
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