Department of Otorhinolaryngology, Aichi Medical University, Nagakute, Aichi, Japan; Department of Otorhinolaryngology, National Center for Geriatrics and Gerontology, Aichi, Japan.
Laryngoscope. 2013 Nov;123(11):E59-65. doi: 10.1002/lary.24298. Epub 2013 Aug 5.
OBJECTIVES/HYPOTHESIS: Endothelin-1 is a potent vasoconstrictor peptide that is widely distributed throughout the mammalian body including the spiral modiolar artery, vestibule, and cochlea. This study aimed to investigate the association between the Lys198Asn (G/T) polymorphism (rs5370) of the endothelin-1 gene and sudden sensorineural hearing loss (SSNHL).
Case-control study.
Seventy-two SSNHL patients (mean age, 58.3 ± 14.0 years) were compared with 2,159 controls included in a community-based study of aging. Multiple logistic regression was used to obtain odds ratios (ORs) for SSNHL. In subgroup analysis, patients with SSNHL who visited to the hospital within the first month of onset were selected to assess audiometric features according to genotype. Pure-tone averages at 250, 500, 1,000, 2,000, and 4,000 Hz were calculated in the affected ear.
Under the recessive genetic model, after adjustment for age, sex, histories of hypertension, dyslipidemia and diabetes, the crude and adjusted ORs for SSNHL risk were 2.209 (95% confidence interval [CI]: 1.140-4.281) and 2.173 (95% CI: 1.086-4.348), respectively. No significant ORs were observed under the additive and dominant models. The severity of SSNHL differed significantly between genotypes. The mean pure-tone averages at the initial visit were 78.6, 66.4, and 57.8 dB for the GG, GT, and TT genotypes, respectively (P = .034).
Our study indicates that the recessive genotype was significantly associated with increased SSNHL risk; however, the severity was lower in these individuals than it was in those with the wild-type genotype. Endothelin-1 may be implicated in SSNHL.
目的/假设：内皮素-1 是一种有效的血管收缩肽，广泛分布于哺乳动物体内，包括螺旋蜗轴动脉、前庭和耳蜗。本研究旨在探讨内皮素-1 基因 Lys198Asn（G/T）多态性（rs5370）与突发性聋（SSNHL）之间的关联。
病例对照研究。
72 例 SSNHL 患者（平均年龄 58.3±14.0 岁）与参加社区老龄化研究的 2159 名对照者进行比较。多因素 logistic 回归分析 SSNHL 的比值比（ORs）。在亚组分析中，选择发病后 1 个月内就诊的 SSNHL 患者，根据基因型评估听力特征。计算受影响耳的 250、500、1000、2000 和 4000 Hz 的纯音平均听阈。
在隐性遗传模型下，调整年龄、性别、高血压、血脂异常和糖尿病史后，SSNHL 风险的粗和调整 OR 分别为 2.209（95%可信区间[CI]：1.140-4.281）和 2.173（95% CI：1.086-4.348）。加性和显性模型下未见显著 OR。基因型之间 SSNHL 的严重程度差异显著。初次就诊时的平均纯音平均听阈分别为 GG、GT 和 TT 基因型的 78.6、66.4 和 57.8 dB（P=0.034）。
本研究表明，隐性基因型与 SSNHL 风险显著相关；然而，这些个体的严重程度低于野生型基因型。内皮素-1 可能与 SSNHL 有关。
