对添加腺嘌呤的枸橼酸盐-磷酸盐-葡萄糖（CPD）血液的研究。

Studies on citrate-phosphate-dextrose (CPD) blood supplemented with adenine.

作者信息

Akerblom O, Kreuger A

出版信息

Vox Sang. 1975;29(2):90-100. doi: 10.1111/j.1423-0410.1975.tb00484.x.

DOI:10.1111/j.1423-0410.1975.tb00484.x

Abstract

The effect of varying adenine concentrations in citrate-phosphate-dextrose (CPD) blood was studied in an attempt to optimize the storage conditions for human erythrocytes with regard to posttransfusion viability and oxygen release function. The maintenance of diphosphoglycerate (DPG) was impaired by adenine supplementation; this effect was closely related to the adenine concentration. A 0.25 mM adenine concentration in CPD blood improved the adenosine triphosphate (ATP) levels and the posttransfusion viability markedly, without appreciably impairing the DPG maintenance. The results suggest that CPD solution supplemented with adenine to give a 0.25 mM concentration in the blood is a better preservative for human erythrocytes than the commonly used acid-citrate-dextrose (ACD), CPD, and ACD-adenine solutions with regard to posttransfusion viability and oxygen release function. Adenine addition to this low concentration is not expected to cause renal damage even after massive transfusion.

摘要

研究了柠檬酸盐 - 磷酸盐 - 葡萄糖（CPD）血液中不同腺嘌呤浓度的影响，旨在优化人红细胞的储存条件，使其在输血后的生存能力和氧释放功能方面达到最佳状态。补充腺嘌呤会损害二磷酸甘油酸（DPG）的维持；这种效应与腺嘌呤浓度密切相关。CPD血液中0.25 mM的腺嘌呤浓度可显著提高三磷酸腺苷（ATP）水平和输血后的生存能力，且不会明显损害DPG的维持。结果表明，就输血后的生存能力和氧释放功能而言，添加腺嘌呤使血液中浓度达到0.25 mM的CPD溶液，比常用的酸性枸橼酸盐葡萄糖（ACD）、CPD和ACD - 腺嘌呤溶液更适合作为人红细胞的保存剂。即使大量输血后，添加低浓度的腺嘌呤也不太可能导致肾损伤。