Jäger W, Feistel H, Paterok E M, Ronay G, Tulusan A H, Wolf F, Lang N
Department of Obstetrics and Gynecology, University of Erlangen-Nürnberg, FRG.
Br J Cancer Suppl. 1990 Jul;10:18-20.
A hand-held probe has been used to localise the 131I-labelled antibody OC125 during second-look operation (SLO) in 22 ovarian cancer patients. In six patients microscopic cancer was detected with the procedure and a further six patients with areas of increased radioactivity during SLO developed recurrent disease within 1-4 months. We suggest examining resection guided by antibodies as a possible means of removing antigen-producing cancerous tissues during surgery.
在22例卵巢癌患者的二次探查手术(SLO)中,使用手持探头对131I标记的抗体OC125进行定位。在6例患者中,通过该操作检测到微小癌,另有6例在二次探查手术期间放射性增强区域的患者在1 - 4个月内出现复发性疾病。我们建议将抗体引导下的切除术作为手术中切除产生抗原的癌组织的一种可能方法进行研究。