Sudour-Bonnange Hélène, Tabone Marie-Dominique, Thomas-Teinturier Cécile, Pacquement Hélène, Oberlin Odile, Marec-Berard Perrine, Laurence Valérie, Aubier Françoise, Duranteau Lise, Bernier-Chastagner Valérie, Michel Gérard, Rives Nathalie, Berger Claire
Centre Oscar-Lambret, Département de Pédiatrie, 3 Rue Fréderic-Combemale, 59020 Lille cedex, France.
Bull Cancer. 2013 Jul-Aug;100(7-8):727-35. doi: 10.1684/bdc.2013.1790.
Given the excellent survival rate of children and teenagers treated for cancer, careful should be given in order to minimize long-term late effects of treatments and to improve quality of life. In this regard, fertility preservation is particularly important. Age, sex and concomitant therapies have an impact on the level of risk of hypofertility, with a stronger risk for chemotherapeutic regimens including alkylating agents, and gonads or hypothalamo-pituitary axis radiotherapy. Assessment of gonadotoxic impact of treatment strategy and fertility preservation techniques are crucial for limiting late effects. The objective of this literature review is to develop guidance for pediatric oncologists and hematologists relative to fertility preservation methods, in children and teenagers receiving gonadotoxic treatment. Specific follow-up after treatment is also proposed.
鉴于接受癌症治疗的儿童和青少年有着出色的生存率，应谨慎行事，以尽量减少治疗的长期后期影响并提高生活质量。在这方面，生育力保存尤为重要。年龄、性别和伴随治疗会对生育力低下的风险水平产生影响，使用包括烷化剂的化疗方案以及性腺或下丘脑-垂体轴放疗的风险更高。评估治疗策略和生育力保存技术的性腺毒性影响对于限制后期影响至关重要。这篇文献综述的目的是为接受性腺毒性治疗的儿童和青少年的儿科肿瘤学家和血液学家制定关于生育力保存方法的指南。还建议了治疗后的具体随访措施。
