大鼠胰岛素样生长因子II基因区域的一级结构。
The primary structure of the rat insulin-like growth factor II gene region.
作者信息
Ikejiri K, Ueno T, Matsuguchi T, Takahashi K, Endo H, Yamamoto M
机构信息
Department of Biochemistry, Kyushu University, Fukuoka, Japan.
出版信息
Biochim Biophys Acta. 1990 Jul 30;1049(3):350-3. doi: 10.1016/0167-4781(90)90110-n.
Complete nucleotide sequences of the rat insulin-like growth factor II gene region including 5' 18 kilobases (kb) up to the insulin gene, all exonic and intronic, and 3' 6 kb sequences were determined. Among these sequences several repetitive stretches became evident besides integration of type II Alu and identifier sequences. They were: (1) twelve repetitions of about 100 base pair (bp) units; (2) duplication of 60 bp units; (3) triplication of a 24 bp unit; and (4) 41-fold expansion of 12-15 bp units.
测定了大鼠胰岛素样生长因子II基因区域的完整核苷酸序列，包括胰岛素基因上游5'端18千碱基（kb）、所有外显子和内含子，以及3'端6 kb序列。在这些序列中，除了II型Alu序列和识别序列的整合外，还发现了几个重复片段。它们分别是：（1）约100个碱基对（bp）单位的十二次重复；（2）60 bp单位的重复；（3）一个24 bp单位的三次重复；以及（4）12 - 15 bp单位的41倍扩增。
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