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多模式镇痛疗法可减少踝关节和后足融合患者的住院时间。

Multimodal analgesia therapy reduces length of hospitalization in patients undergoing fusions of the ankle and hindfoot.

机构信息

Department of Orthopaedics and Rehabilitation, University of Vermont College of Medicine, Burlington, VT, USA.

出版信息

Foot Ankle Int. 2013 Nov;34(11):1526-34. doi: 10.1177/1071100713496224. Epub 2013 Jul 8.

Abstract

BACKGROUND

Multimodal postoperative analgesia employs multiple medications given perioperatively to block the generation and perception of pain at different points in the nociceptive pathway. This retrospective study examines its effect on the length of stay for patients undergoing hindfoot and ankle fusions.

METHODS

All patients operated upon by the senior authors between 2007 and 2011, inclusive, underwent ankle fusion, subtalar fusion, pantalar arthrodesis, triple arthrodesis, or combined ankle/subtalar fusions. The perioperative pain management was either the "traditional" method (patient-controlled-analgesia-delivered parenteral narcotics beginning immediately postoperatively) or the multimodal pain protocol (pre- and postoperative oral administration of opioids, celecoxib, pregabalin, acetaminophen, and prednisone). The choice of pain protocol was up to the surgeons, without any exclusion criteria. Physical therapy protocols were not changed during the study. The study included 220 patients; 175 received the multimodal protocol and 45 received traditional management. Multimodal protocol patients were younger (53.9 vs 59.7 years; P < .003), but there were no other differences between the groups with respect to gender, obesity, body mass index, tobacco use, alcohol use, or comorbidities. Complex cases (revision surgeries, Charcot joint surgeries, multiple concurrent procedures, etc) were equally represented in both groups.

RESULTS

Multimodal protocol patients had lower lengths of stay (2.5 days; 95% confidence interval [CI], 1.4-3.7) than traditional pain management patients (4.2 days; 95% CI, 2.7-5.7; P < .001). This was also true for both complicated and uncomplicated surgeries when considered separately.

CONCLUSION

This study provides the first evidence that multimodal therapy reduces the length of stay for patients undergoing major hindfoot or ankle fusion surgery, regardless of surgical complexity.

LEVEL OF EVIDENCE

Level III, comparative series.

摘要

背景

多模式术后镇痛采用多种药物在围手术期使用,以阻断伤害感受通路不同部位的疼痛产生和感知。本回顾性研究检查了其对接受后足和踝关节融合术患者住院时间的影响。

方法

所有在 2007 年至 2011 年期间由资深作者手术的患者均接受踝关节融合术、距下关节融合术、全距骨融合术、三关节融合术或踝关节/距下关节联合融合术。围手术期疼痛管理采用“传统”方法(术后立即给予患者自控镇痛静脉给予阿片类药物)或多模式疼痛方案(术前和术后口服阿片类药物、塞来昔布、普瑞巴林、对乙酰氨基酚和泼尼松)。疼痛方案的选择由外科医生决定,没有任何排除标准。在研究期间,物理治疗方案没有改变。研究共纳入 220 例患者;175 例患者接受多模式方案,45 例患者接受传统治疗。多模式方案患者更年轻(53.9 岁 vs 59.7 岁;P <.003),但两组在性别、肥胖、体重指数、吸烟、饮酒或合并症方面无其他差异。复杂病例(翻修手术、夏科关节手术、同时进行多项手术等)在两组中均有代表性。

结果

多模式方案患者的住院时间较短(2.5 天;95%置信区间 [CI],1.4-3.7),传统疼痛管理患者为 4.2 天(95%CI,2.7-5.7;P <.001)。当分别考虑复杂和非复杂手术时,这也是如此。

结论

本研究首次提供证据表明,多模式治疗可缩短接受大后足或踝关节融合术患者的住院时间,无论手术复杂程度如何。

证据水平

III 级,比较系列。

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