St. Jude Children's Research Hospital, Memphis, Tennessee;
St. Jude Children's Research Hospital, Memphis, Tennessee.
Pediatrics. 2021 Feb;147(2). doi: 10.1542/peds.2020-046219. Epub 2021 Jan 14.
The dramatic increases of opioid use and misuse in the past 15 years have resulted in a focus on the responsible and judicious use of opioids. In this Ethics Rounds, the commentators analyze the case of a 16-year-old girl with lymphoma and opioid misuse whose caregiver may have diverted her opioids. She is now at the end of life and prefers to die at home. The commentators, oncologists, palliative care providers, ethicists, and a medical student agree that supporting the patient's goals and practicing good opioid stewardship are not incompatible. They identify additional information that would be required to analyze the case more fully such as the nature of the evidence for misuse and diversion and whether bias inadvertently contributed to these concerns. They agree that multimodal analgesia, including but not limited to opioids, is important. Safeguards could include a contract, directly observed therapy, and/or urine drug screens. Supervision or removal of a caregiver diverting medication or admission of the patient misusing medications would be alternatives if the initial plan was unsuccessful. Such patient-centered care requires well-developed substance misuse treatment, pain management, and home hospice that are adequately reimbursed.
在过去的 15 年中,阿片类药物的使用和滥用急剧增加,这使得人们更加关注阿片类药物的合理使用。在本期伦理案例讨论中,评论员分析了一例患有淋巴瘤和阿片类药物滥用的 16 岁女孩的案例,其照顾者可能已经将她的阿片类药物转移。她现在已经处于生命末期,并希望在家中离世。评论员、肿瘤学家、姑息治疗提供者、伦理学家和一名医学生一致认为,支持患者的目标和实施良好的阿片类药物管理并不矛盾。他们还确定了需要进一步分析案例所需的其他信息,例如滥用和转移的证据性质,以及是否有偏见无意中导致了这些担忧。他们一致认为,包括但不限于阿片类药物在内的多模式镇痛是很重要的。可以采取一些措施来保障,如签订合同、直接观察治疗和/或尿液药物检测。如果初始计划不成功,可以考虑由监管人员或移除滥用药物的照顾者,或让滥用药物的患者住院,这些都是替代方案。这种以患者为中心的护理需要完善的物质滥用治疗、疼痛管理和家庭临终关怀服务,并得到充分补偿。