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Pediatric pain treatment and prevention for hospitalized children.住院儿童的疼痛治疗与预防
Pain Rep. 2019 Dec 19;5(1):e804. doi: 10.1097/PR9.0000000000000804. eCollection 2020 Jan-Feb.
2
Recent advances in pain treatment for children with serious illness.重症患儿疼痛治疗的最新进展。
Pain Manag. 2019 Nov;9(6):583-596. doi: 10.2217/pmt-2019-0029. Epub 2019 Nov 18.
3
Barriers and facilitators experienced by patients, carers and healthcare professionals when managing symptoms in infants, children and young people at end-of-life: a mixed methods systematic review protocol.终末期婴幼儿、儿童和青少年症状管理中患者、照料者和医护人员所经历的障碍和促进因素:一项混合方法系统评价方案。
BMJ Open. 2019 Jul 27;9(7):e030566. doi: 10.1136/bmjopen-2019-030566.
4
Deliberative Prescription Opioid Misuse Among Adolescents andEmerging Adults: Opportunities for Targeted Interventions.青少年和新兴成年人中谨慎处方类阿片药物滥用:有针对性干预的机会。
J Adolesc Health. 2018 Nov;63(5):594-600. doi: 10.1016/j.jadohealth.2018.07.007.
5
The relationship between household income and patient-reported symptom distress and quality of life in children with advanced cancer: A report from the PediQUEST study.晚期癌症患儿家庭收入与患者报告的症状困扰和生活质量的关系:来自 PediQUEST 研究的报告。
Cancer. 2018 Oct 1;124(19):3934-3941. doi: 10.1002/cncr.31668. Epub 2018 Sep 14.
6
Approaching the third decade of paediatric palliative oncology investigation: historical progress and future directions.步入儿科姑息肿瘤学研究的第三个十年:历史进展与未来方向
Lancet Child Adolesc Health. 2017 Sep;1(1):56-67. doi: 10.1016/S2352-4642(17)30014-7. Epub 2017 Jul 24.
7
Pediatric palliative care in the community.社区儿科姑息治疗。
CA Cancer J Clin. 2015 Jul-Aug;65(4):316-33. doi: 10.3322/caac.21280. Epub 2015 May 7.
8
Symptoms and Distress in Children With Advanced Cancer: Prospective Patient-Reported Outcomes From the PediQUEST Study.晚期癌症患儿的症状与痛苦:来自PediQUEST研究的前瞻性患者报告结局
J Clin Oncol. 2015 Jun 10;33(17):1928-35. doi: 10.1200/JCO.2014.59.1222. Epub 2015 Apr 27.
9
Improved quality of life at end of life related to home-based palliative care in children with cancer.与居家姑息治疗相关的癌症患儿临终生活质量改善
J Palliat Med. 2015 Feb;18(2):143-50. doi: 10.1089/jpm.2014.0285. Epub 2014 Nov 17.
10
Specialized pediatric palliative home care: a prospective evaluation.儿科姑息治疗家庭护理专业化:前瞻性评估。
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阿片类药物在成瘾濒死儿童中的管理。

Opioid Management in the Dying Child With Addiction.

机构信息

St. Jude Children's Research Hospital, Memphis, Tennessee;

St. Jude Children's Research Hospital, Memphis, Tennessee.

出版信息

Pediatrics. 2021 Feb;147(2). doi: 10.1542/peds.2020-046219. Epub 2021 Jan 14.

DOI:10.1542/peds.2020-046219
PMID:33446508
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7849194/
Abstract

The dramatic increases of opioid use and misuse in the past 15 years have resulted in a focus on the responsible and judicious use of opioids. In this Ethics Rounds, the commentators analyze the case of a 16-year-old girl with lymphoma and opioid misuse whose caregiver may have diverted her opioids. She is now at the end of life and prefers to die at home. The commentators, oncologists, palliative care providers, ethicists, and a medical student agree that supporting the patient's goals and practicing good opioid stewardship are not incompatible. They identify additional information that would be required to analyze the case more fully such as the nature of the evidence for misuse and diversion and whether bias inadvertently contributed to these concerns. They agree that multimodal analgesia, including but not limited to opioids, is important. Safeguards could include a contract, directly observed therapy, and/or urine drug screens. Supervision or removal of a caregiver diverting medication or admission of the patient misusing medications would be alternatives if the initial plan was unsuccessful. Such patient-centered care requires well-developed substance misuse treatment, pain management, and home hospice that are adequately reimbursed.

摘要

在过去的 15 年中,阿片类药物的使用和滥用急剧增加,这使得人们更加关注阿片类药物的合理使用。在本期伦理案例讨论中,评论员分析了一例患有淋巴瘤和阿片类药物滥用的 16 岁女孩的案例,其照顾者可能已经将她的阿片类药物转移。她现在已经处于生命末期,并希望在家中离世。评论员、肿瘤学家、姑息治疗提供者、伦理学家和一名医学生一致认为,支持患者的目标和实施良好的阿片类药物管理并不矛盾。他们还确定了需要进一步分析案例所需的其他信息,例如滥用和转移的证据性质,以及是否有偏见无意中导致了这些担忧。他们一致认为,包括但不限于阿片类药物在内的多模式镇痛是很重要的。可以采取一些措施来保障,如签订合同、直接观察治疗和/或尿液药物检测。如果初始计划不成功,可以考虑由监管人员或移除滥用药物的照顾者,或让滥用药物的患者住院,这些都是替代方案。这种以患者为中心的护理需要完善的物质滥用治疗、疼痛管理和家庭临终关怀服务,并得到充分补偿。