胃癌循环内皮祖细胞的鉴定及其临床意义。
Identification and clinical significance of circulating endothelial progenitor cells in gastric cancer.
机构信息
Department Clinical Laboratory, Lanzhou Military Command General Hospital of the People's Liberation Army and Key Laboratory of Stem Cell and Gene Medicine of Gansu Province , Lanzhou, Gansu , China and.
出版信息
Biomarkers. 2013 Sep;18(6):487-92. doi: 10.3109/1354750X.2013.810666. Epub 2013 Jul 9.
CONTEXT
There are few reports of endothelial progenitor cells (EPCs) in peripheral blood have been found in patients with gastric cancer.
OBJECTIVE
We quantified EPCs in the peripheral blood of patients with gastric cancer, with the expectation that this approach might lead to a new marker for the diagnosis of gastric cancer.
METHODS
We enumerated CD34+/CD133+ EPCs in the peripheral blood of 145 subjects by use of flow cytometry.
RESULTS AND CONCLUSION
The quantity of peripheral blood EPCs in patients with gastric cancer are correlated with patient's age. In addition, the number of peripheral blood EPCs in patients with gastric cancer increased with tumor node metastasis stage and histological differentiation of the cancers, and with the operative status of the patients.
背景
目前在胃癌患者的外周血中发现内皮祖细胞（EPCs）的报道很少。
目的
我们对外周血中的胃癌患者 EPCs 进行了定量，希望这一方法能为胃癌的诊断提供新的标志物。
方法
采用流式细胞术对 145 例患者的外周血中的 CD34+/CD133+ EPCs 进行了计数。
结果与结论
胃癌患者外周血 EPCs 的数量与患者的年龄相关。此外，胃癌患者外周血 EPCs 的数量与肿瘤淋巴结转移分期、肿瘤的组织学分化以及患者的手术状态有关。
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