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The potential for targeting the STAT3 pathway as a novel therapy for melanoma.

作者信息

Lesinski Gregory B

出版信息

Future Oncol. 2013 Jul;9(7):925-7. doi: 10.2217/fon.13.83.

Abstract
摘要

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本文引用的文献

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Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor.
Oncogene. 2014 Feb 27;33(9):1158-66. doi: 10.1038/onc.2013.45. Epub 2013 Mar 4.
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Molecular pathways: Jak/STAT pathway: mutations, inhibitors, and resistance.
Clin Cancer Res. 2013 Apr 15;19(8):1933-40. doi: 10.1158/1078-0432.CCR-12-0284. Epub 2013 Feb 13.
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Stat3-targeted therapies overcome the acquired resistance to vemurafenib in melanomas.
J Invest Dermatol. 2013 Aug;133(8):2041-9. doi: 10.1038/jid.2013.32. Epub 2013 Jan 23.
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Inhibiting EGF receptor or SRC family kinase signaling overcomes BRAF inhibitor resistance in melanoma.
Cancer Discov. 2013 Feb;3(2):158-67. doi: 10.1158/2159-8290.CD-12-0386. Epub 2012 Dec 14.
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Orally bioavailable small-molecule inhibitor of transcription factor Stat3 regresses human breast and lung cancer xenografts.
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Targeting STAT3 in adoptively transferred T cells promotes their in vivo expansion and antitumor effects.
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Inhibition of mutated, activated BRAF in metastatic melanoma.
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