Filimon Anca, Preda Iulia A, Boloca Adina F, Negroiu Gabriela
Group of Molecular Cell Biology, Institute of Biochemistry of the Romanian Academy, 060031 Bucharest, Romania.
Cells. 2021 Dec 30;11(1):120. doi: 10.3390/cells11010120.
Cutaneous melanoma accounts for only about 7% of skin cancers but is causing almost 90% of deaths. Melanoma cells have a distinct repertoire of mutations from other cancers, a high plasticity and degree of mimicry toward vascular phenotype, stemness markers, versatility in evading and suppress host immune control. They exert a significant influence on immune, endothelial and various stromal cells which form tumor microenvironment. The metastatic stage, the leading cause of mortality in this neoplasm, is the outcome of a complex, still poorly understood, cross-talk between tumor and other cell phenotypes. There is accumulating evidence that Interleukin-8 (IL-8) is emblematic for advanced melanomas. This work aimed to present an updated status of IL-8 in melanoma tumor cellular complexity, through a comprehensive analysis including data from other chemokines and neoplasms. The multiple processes and mechanisms surveyed here demonstrate that IL-8 operates following orchestrated programs within signaling webs in melanoma, stromal and vascular cells. Importantly, the yet unknown molecularity regulating IL-8 impact on cells of the immune system could be exploited to overturn tumor fate. The molecular and cellular targets of IL-8 should be brought into the attention of even more intense scientific exploration and valorization in the therapeutical management of melanoma.
皮肤黑色素瘤仅占皮肤癌的约7%，但却导致了近90%的死亡。黑色素瘤细胞具有与其他癌症不同的突变谱，具有高度的可塑性和对血管表型的模仿程度、干性标志物、逃避和抑制宿主免疫控制的多功能性。它们对形成肿瘤微环境的免疫、内皮和各种基质细胞产生重大影响。转移阶段是这种肿瘤死亡的主要原因，是肿瘤与其他细胞表型之间复杂且仍知之甚少的相互作用的结果。越来越多的证据表明，白细胞介素-8（IL-8）是晚期黑色素瘤的标志性物质。这项工作旨在通过包括来自其他趋化因子和肿瘤的数据的综合分析，呈现IL-8在黑色素瘤肿瘤细胞复杂性方面的最新状况。这里所研究的多个过程和机制表明，IL-8在黑色素瘤、基质和血管细胞的信号网络中按照精心编排的程序发挥作用。重要的是，调节IL-8对免疫系统细胞影响的未知分子机制可被利用来扭转肿瘤命运。IL-8的分子和细胞靶点应在黑色素瘤的治疗管理中引起更深入的科学探索和重视。
