National Center for Nanoscience and Technology (NCNST), Beijing 100190, PR China.
Nanoscale. 2013 Sep 21;5(18):8288-306. doi: 10.1039/c3nr01630g.
The control of the DNA condensation process is essential for compaction of DNA in chromatin, as well as for biological applications such as nonviral gene therapy. This review endeavours to reflect the progress of investigations on DNA condensation effects of nanostructure-based condensing agents (such as nanoparticles, nanotubes, cationic polymer and peptide agents) observed by using atomic force microscopy (AFM) and other techniques. The environmental effects on structural characteristics of nanostructure-induced DNA condensates are also discussed.
DNA 凝聚过程的控制对于染色质中 DNA 的压缩以及非病毒基因治疗等生物应用至关重要。本综述旨在反映使用原子力显微镜（AFM）和其他技术观察到的基于纳米结构的凝聚剂（如纳米粒子、纳米管、阳离子聚合物和肽类试剂）对 DNA 凝聚效应的研究进展。还讨论了环境对纳米结构诱导的 DNA 凝聚物结构特征的影响。
