Newton D W, Rogers A G, Becker C H, Torosian G
Am J Hosp Pharm. 1975 Aug;32(8):817-21.
The stability of methyldopa in two extemporaneous syrup preparations was studied. Film-coated methyldopa tablets were triturated and incorporated into (1) unpreserved Syrup USP and (2) an equal mixture of simple syrup containing 0.5% citric acid and 0.2 N hydrochloric acid, in concentrations of 50 mg/ml. The preparations were stored in the dark, for 14 days at 5 C and 25 C. Samples were analyzed spectrophotometrically for methyldopa content at various intervals. Both preparations were stable under the conditions studied.
研究了甲基多巴在两种临时配制糖浆制剂中的稳定性。将薄膜包衣甲基多巴片研磨后加入到（1）未加防腐剂的美国药典糖浆和（2）含0.5%柠檬酸和0.2N盐酸的单糖浆等量混合物中，浓度为50mg/ml。制剂在暗处5℃和25℃下储存14天。在不同时间间隔用分光光度法分析样品中甲基多巴的含量。在所研究的条件下，两种制剂均稳定。
