Arocker-Mettinger E, Asenbauer T, Ulbrich S, Grabner G
2nd Department of Ophthalmology, University of Vienna, Austria.
Curr Eye Res. 1990;9 Suppl:25-9. doi: 10.3109/02713689008999415.
This study reports on serum interleukin 2-receptor (IL-2R) levels in uveitis patients. IL-2R is the mediator protein of interleukin 2 (IL-2), a mitogenetic cytokine of primarily immune cell interaction. Stimulated T-cells readily express IL-2R on their cell surface and release a soluble form into serum. The measurement of IL-2R serum levels was performed using a monoclonal antibody based ELISA with age and sex matched healthy blood donors serving as the control group. The increase of IL-2R serum levels in patients affected by heterochromic cyclitis Fuchs (HCF) and a small group of children with chronic anterior uveitis affected by juvenile rheumatoid arthritis (JRA) was statistically highly significant, when compared to the control group (n = 84, alpha = 0.01). Serum levels of patients with intermediate uveitis (IU), patients with HLA-B27 positive acute anterior uveitis (AAU) and patients with HLA-B27 negative AAU did not differ significantly from the controls.
本研究报告了葡萄膜炎患者血清白细胞介素2受体（IL-2R）水平。IL-2R是白细胞介素2（IL-2）的介质蛋白，IL-2是主要参与免疫细胞相互作用的促有丝分裂细胞因子。受刺激的T细胞易于在其细胞表面表达IL-2R，并向血清中释放可溶性形式。使用基于单克隆抗体的酶联免疫吸附测定法（ELISA）测量IL-2R血清水平，以年龄和性别匹配的健康献血者作为对照组。与对照组（n = 84，α = 0.01）相比，富克斯异色性睫状体炎（HCF）患者以及一小部分受幼年类风湿性关节炎（JRA）影响的慢性前葡萄膜炎儿童患者的IL-2R血清水平升高具有高度统计学意义。中间葡萄膜炎（IU）患者、HLA-B27阳性急性前葡萄膜炎（AAU）患者和HLA-B27阴性AAU患者的血清水平与对照组无显著差异。
