Department of Nutritional Sciences and Toxicology, University of California , Berkeley, CA , USA.
Front Endocrinol (Lausanne). 2013 Jul 3;4:79. doi: 10.3389/fendo.2013.00079. eCollection 2013.
Preadipocyte factor 1 (Pref-1, also called Dlk1/FA1) is a molecular gatekeeper of adipogenesis which acts by maintaining the preadipocyte state and preventing adipocyte differentiation. Pref-1 is made as an epidermal growth factor-like repeat containing transmembrane protein, and is cleaved by TNFα-converting enzyme (TACE) to generate a soluble form, which acts as an autocrine/paracrine factor. Pref-1 upregulates Sox9 expression by activating the ERK/MAPK pathway and the Pref-1 interaction with fibronectin is required for inhibition of adipogenesis. Pref-1 also prevents brown adipocyte differentiation and its thermogenic function. Here, we highlight the recent evidence for the role of Pref-1 in adipogenesis.
前脂肪细胞因子 1（Pref-1，也称为 Dlk1/FA1）是脂肪生成的分子守门员，通过维持前脂肪细胞状态和防止脂肪细胞分化来发挥作用。Pref-1 作为一种表皮生长因子样重复含跨膜蛋白合成，并被 TNFα 转化酶（TACE）切割生成可溶性形式，作为自分泌/旁分泌因子发挥作用。Pref-1 通过激活 ERK/MAPK 通路而上调 Sox9 表达，Pref-1 与纤维连接蛋白的相互作用对于抑制脂肪生成是必需的。Pref-1 还防止棕色脂肪细胞分化及其产热功能。在这里，我们强调了 Pref-1 在脂肪生成中的作用的最新证据。
