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静脉注射曲马多所致急性谵妄

Acute Delirium due to Parenteral Tramadol.

作者信息

Ghosh Soumitra, Mondal Supriya Kumar, Bhattacharya Arnab, Saddichha Sahoo

机构信息

Department of Psychiatry, Silchar Medical College, Assam, India.

出版信息

Case Rep Emerg Med. 2013;2013:492685. doi: 10.1155/2013/492685. Epub 2013 Jun 6.

DOI:10.1155/2013/492685
PMID:23840975
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3690220/
Abstract

Tramadol is a widely used medication by physicians and is held to be a safe analgesic. It has been claimed to be helpful in the elderly and hepatic and renally compromised subjects. We would like to report a case of delirium in a middle-aged female with acute pain abdomen on tramadol while being treated in the surgical unit. The patient developed alteration in the level of consciousness and cognitive deficits following injectable dose of tramadol. She was diagnosed as a case of tramadol-induced delirium. The patient improved spontaneously after stoppage of tramadol injection. The probable mechanism for development of tramadol-induced delirium is discussed along with clinical implications.

摘要

曲马多是医生广泛使用的药物,被认为是一种安全的镇痛药。据称它对老年人以及肝脏和肾脏功能受损的患者有帮助。我们想报告一例在外科病房接受治疗的中年女性,因急性腹痛使用曲马多后出现谵妄的病例。患者在注射曲马多后出现意识水平改变和认知缺陷。她被诊断为曲马多诱发的谵妄。停用曲马多注射后,患者自行好转。本文讨论了曲马多诱发谵妄的可能机制及其临床意义。

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Acute Delirium due to Parenteral Tramadol.静脉注射曲马多所致急性谵妄
Case Rep Emerg Med. 2013;2013:492685. doi: 10.1155/2013/492685. Epub 2013 Jun 6.
2
Unrecognised long-lasting tramadol-induced delirium in two elderly patients. A case report.两例老年患者中未被识别的长期曲马多诱发的谵妄。病例报告。
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[Tramadol in acute pain].[曲马多用于急性疼痛]
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Control of acute pain after major abdominal surgery in 585 patients given tramadol and ketorolac by intravenous infusion.585例接受静脉输注曲马多和酮咯酸的患者腹部大手术后急性疼痛的控制情况。
Drugs Exp Clin Res. 2002;28(2-3):113-8.
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Impaired mobility, ASA status and administration of tramadol are risk factors for postoperative delirium in patients aged 75 years or more after major abdominal surgery.在 75 岁或以上的大腹部手术后患者中,活动受限、ASA 状态和曲马多给药是术后谵妄的危险因素。
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The problem of pain: Additive analgesic effect of tramadol and buprenorphine in a patient with opioid use disorder.疼痛问题:曲马多和丁丙诺啡联合用于阿片类药物使用障碍患者的增效镇痛作用。
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[Effectiveness and tolerance of tramadol in cancer pain. A comparative study with respect to buprenorphine].曲马多治疗癌痛的有效性和耐受性。与丁丙诺啡的比较研究
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Capturing side-effect of medication to identify persons at risk of delirium.捕捉药物的副作用以识别谵妄风险人群。
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引用本文的文献

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Delirium Research in India: A Systematic Review.印度的谵妄研究:一项系统综述。
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Tramadol-associated hallucinations: a systematic review and narrative synthesis of their pathophysiology, diagnosis, and treatment.曲马多相关性幻觉:对其病理生理学、诊断和治疗的系统回顾和叙述性综合。
Can J Anaesth. 2020 Mar;67(3):360-368. doi: 10.1007/s12630-019-01548-9. Epub 2019 Dec 16.
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Delirium induced by tigecycline treatment for Acinetobacter baumannii infection: A case report.替加环素治疗鲍曼不动杆菌感染所致谵妄:一例报告。
Medicine (Baltimore). 2019 May;98(19):e15399. doi: 10.1097/MD.0000000000015399.
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The Comparative Risk of Delirium with Different Opioids: A Systematic Review.不同阿片类药物所致谵妄的比较风险:一项系统评价
Drugs Aging. 2017 Jun;34(6):437-443. doi: 10.1007/s40266-017-0455-9.
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Opium Withdrawal Delirium: Two Case Reports.鸦片戒断谵妄:两例报告
Psychopharmacol Bull. 2017 Jan 26;47(1):48-51.

本文引用的文献

1
Severe delirium following single dose of tramadol.
Indian J Med Sci. 2009 Feb;63(2):80-1.
2
Unrecognised long-lasting tramadol-induced delirium in two elderly patients. A case report.两例老年患者中未被识别的长期曲马多诱发的谵妄。病例报告。
Pharmacopsychiatry. 2006 Sep;39(5):194-9. doi: 10.1055/s-2006-948331.
3
The effects of the tramadol metabolite O-desmethyl tramadol on muscarinic receptor-induced responses in Xenopus oocytes expressing cloned M1 or M3 receptors.曲马多代谢物O-去甲基曲马多对表达克隆的M1或M3受体的非洲爪蟾卵母细胞中由毒蕈碱受体诱导的反应的影响。
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5
Tramadol: a new centrally acting analgesic.曲马多:一种新型中枢性镇痛药。
Am J Health Syst Pharm. 1997 Mar 15;54(6):643-52. doi: 10.1093/ajhp/54.6.643.
6
A method for estimating the probability of adverse drug reactions.一种估算药物不良反应概率的方法。
Clin Pharmacol Ther. 1981 Aug;30(2):239-45. doi: 10.1038/clpt.1981.154.