Stockl Thomas, Ross Jeffrey S, Walter Otto, Dresser Karen, Lee Hwajeong
1University of Massachusetts, Worcester, MA, USA.
Int J Surg Pathol. 2013 Dec;21(6):603-9. doi: 10.1177/1066896913494795. Epub 2013 Jul 9.
Recognition of an appendiceal diverticulum is important because of its association with an appendiceal neoplasm. The incidence of mucosal Schwann cell proliferation in 24 cases of appendiceal diverticular disease, 17 serrated polyps, 4 cases of mucosal hyperplasia, and 45 normal appendices was determined. Ten (42%) of 24 cases with diverticula, 2 (50%) of 4 cases of mucosal hyperplasia with concurrent surface low-grade dysplasia, and 9 (20%) of 45 cases of normal appendices showed mucosal Schwann cell proliferation. It was not seen within the 17 cases of serrated polyps. Mucosal Schwann cell proliferation is common in appendiceal diverticular disease and may serve as a histologic marker for the presence of an appendiceal diverticulum. Thus, when routine histologic sections of a removed appendix demonstrate Schwann cell proliferation, further examination of the specimen may detect possible coexisting diverticular disease, which in turn may be associated with appendiceal neoplasms and epithelial dysplasia.
认识阑尾憩室很重要，因为它与阑尾肿瘤有关。测定了24例阑尾憩室病、17例锯齿状息肉、4例黏膜增生以及45例正常阑尾中黏膜施万细胞增殖的发生率。24例憩室病例中有10例（42%）、4例伴有表面低级别发育异常的黏膜增生病例中有2例（50%）以及45例正常阑尾病例中有9例（20%）出现黏膜施万细胞增殖。在17例锯齿状息肉中未见到这种情况。黏膜施万细胞增殖在阑尾憩室病中很常见，可能作为阑尾憩室存在的组织学标志物。因此，当切除阑尾的常规组织切片显示施万细胞增殖时，对标本进行进一步检查可能会发现可能并存的憩室病，而憩室病反过来可能与阑尾肿瘤和上皮发育异常有关。
