网状假性色素沉着对黄斑功能的影响。

Impact of reticular pseudodrusen on macular function.

机构信息

*Department of Ophthalmology, Centre Hospitalier Intercommunal de Creteil University Paris Est Creteil, Creteil, France; and †Department of Ophthalmology, Hospital San Raffaele, University Vita Salute San Raffaele, Milan, Italy.

出版信息

Retina. 2014 Feb;34(2):321-9. doi: 10.1097/IAE.0b013e3182993df1.

DOI:10.1097/IAE.0b013e3182993df1

PMID:23842105

Abstract

PURPOSE

To investigate the impact of reticular pseudodrusen on macular function using microperimetry.

METHODS

Eighteen consecutive patients (18 eyes) with reticular pseudodrusen (Group 1), and without medium/large drusen, underwent microperimetry. Eighteen age-matched and sex-matched subjects (18 eyes) with typical drusen and without pseudodrusen (Group 2) also underwent microperimetry. Macular sensitivity was assessed by microperimetry and compared between the two Groups.

RESULTS

Mean age of patients with reticular pseudodrusen and with typical drusen was 77.3 ± 6.8 years and 75.0 ± 9.9 years, respectively (P = 0.4), and 61.1% and 61.1% were women, respectively. Mean best-corrected visual acuity was 0.14 ± 0.09 logarithm of the minimum angle of resolution and 0.13 ± 0.09 logarithm of the minimum angle of resolution (P = 0.8) in Group 1 and Group 2, respectively. Microperimetry revealed a significant difference in overall mean macular sensitivity ("square 7 × 7"; 49 points) between Group 1 and Group 2 (5.9 ± 1.7 dB vs. 8.8 ± 2.4 dB, P < 0.001). Both mean central macular sensitivity ("square 3 × 3"; 9 points) and mean peripheral macular microperimetric sensitivity (overall "square 7 × 7" - central "square 3 × 3"; 40 points) were significantly reduced in Group 1 compared with Group 2 (central macular sensitivity: 6.9 ± 1.7 dB vs. 8.9 ± 2.6 dB in Group 1 and Group 2, respectively; P = 0.01; peripheral macular sensitivity: 5.7 ± 1.8 dB vs. 8.7 ± 2.3 dB in Group 1 and Group 2, respectively; P < 0.001). In Group 1, mean peripheral sensitivity was reduced when compared with mean central sensitivity (5.7 ± 1.8 dB vs. 6.9 ± 1.7 dB, P = 0.01), whereas in Group 2, mean sensitivity was similar in both peripheral and central macula (8.7 ± 2.3 dB vs. 8.9 ± 2.6 dB, P = 0.4).

CONCLUSION

Eyes with reticular pseudodrusen present a greater extent of reduced sensitivity than eyes with typical drusen.

摘要

目的

使用微视野计研究网状假性玻璃膜疣对黄斑功能的影响。

方法

连续纳入 18 例（18 只眼）患有网状假性玻璃膜疣（第 1 组）且无中/大玻璃膜疣的患者，并对其进行微视野计检查。同时纳入 18 例年龄和性别相匹配（18 只眼）且患有典型玻璃膜疣但无假性玻璃膜疣（第 2 组）的患者，也对其进行微视野计检查。通过微视野计评估黄斑敏感性，并比较两组之间的差异。

结果

第 1 组和第 2 组患者的平均年龄分别为 77.3±6.8 岁和 75.0±9.9 岁（P=0.4），且分别有 61.1%和 61.1%为女性。第 1 组和第 2 组的最佳矫正视力分别为 0.14±0.09 对数最小角分辨率和 0.13±0.09 对数最小角分辨率（P=0.8）。微视野计检查发现，第 1 组的整体平均黄斑敏感性（“正方形 7×7”；49 分）与第 2 组相比存在显著差异（5.9±1.7dB 比 8.8±2.4dB，P<0.001）。与第 2 组相比，第 1 组的平均中央黄斑敏感性（“正方形 3×3”；9 分）和平均周边黄斑微视野计敏感性（整体“正方形 7×7”-中央“正方形 3×3”；40 分）均显著降低（中央黄斑敏感性：6.9±1.7dB 比第 1 组和第 2 组的 8.9±2.6dB，P=0.01；周边黄斑敏感性：5.7±1.8dB 比第 1 组和第 2 组的 8.7±2.3dB，P<0.001）。第 1 组的平均周边敏感性与平均中央敏感性相比有所降低（5.7±1.8dB 比 6.9±1.7dB，P=0.01），而第 2 组的周边和中央黄斑的平均敏感性相似（8.7±2.3dB 比 8.9±2.6dB，P=0.4）。