Kumar Himeesh, Guymer Robyn H, Hodgson Lauren A B, Hadoux Xavier, Jannaud Maxime, van Wijngaarden Peter, Luu Chi D, Wu Zhichao
Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, Australia.
Department of Surgery (Ophthalmology), The University of Melbourne, Melbourne, Australia.
Ophthalmol Sci. 2024 May 8;4(6):100551. doi: 10.1016/j.xops.2024.100551. eCollection 2024 Nov-Dec.
To understand the spatial relationship between local rod-mediated visual function and reticular pseudodrusen (RPD) in eyes with large drusen.
Retrospective cross-sectional study.
One eye with large drusen (>125 μm) each from 91 individuals with intermediate age-related macular degeneration, with and without RPD.
All participants underwent dark adaptation testing using a dark-adapted chromatic perimeter, where visual sensitivities were measured over 30 minutes of dark adaptation after photobleach. The rod intercept time (RIT; a measure of dynamic rod function) and pointwise sensitivity difference (PWSD; a relative measure of rod- compared with cone-mediated function) was determined at multiple retinal locations, and their association with the overall (central 20° × 20° region) and local (2° diameter region centered on the location tested) extent of RPD and drusen (quantified using multimodal imaging) was examined.
Association between overall and local extent of RPD and drusen with RIT and PWSD at each retinal location tested.
In a multivariable analysis, delayed RIT was associated with an increasing overall ( < 0.001), but not local ( = 0.884), extent of RPD. In contrast, the increasing local ( < 0.001), but not overall ( = 0.475), extent of drusen was associated with delayed RIT. Furthermore, only an increasing overall extent of RPD ( < 0.001) was associated with reduced PWSD (or worse rod compared with cone function), but not the local extent of RPD and drusen, or overall extent of drusen ( ≥ 0.344).
Local rod-mediated function was associated with the overall, rather than local, extent of RPD in eyes with large drusen, suggesting that there may be widespread pathologic changes in eyes with RPD that account for this.
Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.
了解存在大玻璃膜疣的眼中局部视杆细胞介导的视觉功能与网状假性玻璃膜疣（RPD）之间的空间关系。
回顾性横断面研究。
91例中度年龄相关性黄斑变性患者中，每例患者一只存在大玻璃膜疣（>125μm）的眼睛，其中部分有RPD，部分没有。
所有参与者均使用暗适应彩色视野计进行暗适应测试，在光漂白后30分钟的暗适应过程中测量视觉敏感度。在多个视网膜位置确定视杆细胞截获时间（RIT；动态视杆细胞功能的指标）和逐点敏感度差异（PWSD；视杆细胞与视锥细胞介导功能的相对指标），并检查它们与RPD和玻璃膜疣的总体（中央20°×20°区域）和局部（以测试位置为中心的直径2°区域）范围的相关性（使用多模态成像进行量化）。
在每个测试的视网膜位置，RPD和玻璃膜疣的总体及局部范围与RIT和PWSD之间的相关性。
在多变量分析中，RIT延迟与RPD总体范围增加相关（<0.001），但与局部范围无关（=0.884）。相反，玻璃膜疣局部范围增加（<0.001）与RIT延迟相关，但与总体范围无关（=0.475）。此外，只有RPD总体范围增加（<0.001）与PWSD降低（或视杆细胞与视锥细胞功能相比更差）相关，而与RPD和玻璃膜疣的局部范围或玻璃膜疣的总体范围无关（≥0.344）。
在存在大玻璃膜疣的眼中，局部视杆细胞介导的功能与RPD的总体范围而非局部范围相关，这表明存在RPD的眼睛可能存在广泛的病理变化来解释这一现象。
本文末尾的脚注和披露中可能会找到专有或商业披露信息。
