适体导向的多功能镧系掺杂多孔纳米探针的合成用于靶向成像和药物递送。
Aptamer-directed synthesis of multifunctional lanthanide-doped porous nanoprobes for targeted imaging and drug delivery.
机构信息
Laboratory of Chemical Biology and State, Key Laboratory of Rare Earth Resources Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China, Fax: (+86) 0431-85262625; Graduate School of the Chinese Academy of Sciences, Beijing 100039, China.
出版信息
Small. 2013 Dec 20;9(24):4262-8. doi: 10.1002/smll.201301239. Epub 2013 Jul 11.
Multifunctional lanthanide-doped porous nanoparticles are prepared via a facile one-step solvothermal route by employing aptamers as the biotemplate. The nanoparticles feature excellent aqueous dispersibility and biospecific properties and could work as effective nanoprobes for targeted imaging and drug delivery. With aptamer being in principle available for any kind of target, this synthetic strategy may open the door to a new generation of nanoprobes for bioapplications such as time-resolved biodetection, multimode bioimaging/biolabeling, and targeted cancer therapy.
多功能镧系掺杂多孔纳米粒子通过简便的一步溶剂热路线制备，采用适体作为生物模板。这些纳米粒子具有优异的水分散性和生物特异性，并可用作靶向成像和药物传递的有效纳米探针。由于适体原则上可用于任何类型的靶标，因此这种合成策略可能为生物应用（如时间分辨生物检测、多模式生物成像/标记和靶向癌症治疗）开辟新一代纳米探针的大门。
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