特异性 c7 修饰的秋水仙碱类似物具有异常的微管蛋白聚集能力。
Unusual tubulin-clustering ability of specifically c7-modified colchicine analogues.
机构信息
M. V. Lomonosov Moscow State University, Leninskie Gory, 119992 Moscow, Russian Federation.
出版信息
Chembiochem. 2013 Aug 19;14(12):1444-9. doi: 10.1002/cbic.201300143. Epub 2013 Jul 10.
PMID:23843347
Abstract
Highly cytotoxic C7-modified colchicine analogues, exemplified by tubuloclustin, promote microtubule disassembly followed by the formation of very stable tubulin clusters, both in vitro and in cells. The proposed mechanism of action of tubuloclustin and its analogues, beyond that of colchicine, includes additional specific interactions with the α-tubulin subunit.
摘要
高细胞毒性 C7 修饰的秋水仙碱类似物，以 tubuloclustin 为例，在体外和细胞中均能促进微管解聚，随后形成非常稳定的微管蛋白聚集体。tubuloclustin 及其类似物的作用机制除了秋水仙碱之外，还包括与α-微管蛋白亚基的额外特定相互作用。
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