Zimmermann H P, Doenges K H, Moll E
Eur J Cell Biol. 1982 Feb;26(2):310-4.
A heme-nonapeptide with peroxidase-like activity was conjugated to pure deacetylcolchicine. This conjugated colchicine derivative competitively inhibits colchicine binding to soluble tubulin and is also able to depolymerize microtubules in vitro. Cytochemical studies show that at substoichiometric concentrations of the derivative, microtubules from the same sample are decorated to varying extents. These findings indicate that the binding of the colchicine-derivative to microtubules causes them to depolymerize.
一种具有过氧化物酶样活性的血红素九肽与纯脱乙酰秋水仙碱偶联。这种偶联的秋水仙碱衍生物竞争性抑制秋水仙碱与可溶性微管蛋白的结合，并且在体外也能够使微管解聚。细胞化学研究表明，在亚化学计量浓度的衍生物作用下，来自同一样品的微管会受到不同程度的修饰。这些发现表明，秋水仙碱衍生物与微管的结合会导致它们解聚。
