内源性n-3多不饱和脂肪酸（PUFAs）通过减轻FAT1转基因小鼠的骨髓脂肪生成来缓解卵巢切除诱导的骨质流失。
Endogenous n-3 polyunsaturated fatty acids (PUFAs) mitigate ovariectomy-induced bone loss by attenuating bone marrow adipogenesis in FAT1 transgenic mice.
作者信息
Chen Tian-yu, Zhang Zhong-min, Zheng Xiao-chen, Wang Liang, Huang Min-jun, Qin Si, Chen Jian, Lai Ping-lin, Yang Cheng-liang, Liu Jia, Dai Yi-fan, Jin Da-di, Bai Xiao-chun
机构信息
Department of Orthopaedic, the Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, People's Republic of China.
出版信息
Drug Des Devel Ther. 2013 Jun 28;7:545-52. doi: 10.2147/DDDT.S45263. Print 2013.
Abstract
AIM
To investigate the effect of endogenous n-3 polyunsaturated fatty acids (PUFAs) on bone marrow adipogenesis under osteoporosis conditions.
METHODS
A mouse osteoporosis model overexpressing the FAT1 gene from Caenorhabditis elegans and converting n-6 PUFAs to n-3 PUFAs endogenously was used.
RESULTS
The mice presented significantly lower bone marrow adiposity (adipocyte volume/tissue volume, mean adipocyte number) but increased the bone parameters (bone mineral density, bone mineral content, bone volume/total volume) in the distal femoral metaphysis.
CONCLUSION
Endogenous n-3 PUFAs protect bone marrow adipogenesis, which provides a novel drug target.
摘要
目的
研究内源性n-3多不饱和脂肪酸（PUFAs）在骨质疏松条件下对骨髓脂肪生成的影响。
方法
使用过表达秀丽隐杆线虫FAT1基因并将n-6 PUFAs内源性转化为n-3 PUFAs的小鼠骨质疏松模型。
结果
小鼠股骨远端干骺端的骨髓脂肪含量（脂肪细胞体积/组织体积、平均脂肪细胞数量）显著降低，但骨参数（骨密度、骨矿物质含量、骨体积/总体积）增加。
结论
内源性n-3 PUFAs可保护骨髓脂肪生成，这提供了一个新的药物靶点。
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