Chen Yu-Ling, Chen Chien-Hung, Hu Rey-Heng, Ho Ming-Chih, Jeng Yung-Ming
Graduate Institute of Pathology, National Taiwan University, Taipei 100, Taiwan.
ScientificWorldJournal. 2013 Jun 12;2013:380797. doi: 10.1155/2013/380797. Print 2013.
Serum levels of the tumor marker CA19-9 have been reported to be elevated in patients with hepatocellular carcinoma (HCC), but its clinicopathologic significance is still unknown. A cohort of 304 patients undergoing surgical resection for HCC and having preoperative CA19-9 data was enrolled in this study. Serum CA19-9 levels were correlated with clinicopathologic factors. Univariate and multivariate analyses were performed to determine the predictors of patient survival. On receiver operating characteristic curve analysis, the cut off value of CA19-9 was determined to be 27 U/mL. One hundred and six patients had preoperative CA19-9 values >27 U/mL. High serum CA19-9 levels did not correlate with patient age, sex, viral status, α -fetoprotein level, tumor size, tumor grade, tumor stage, multiplicity, and vascular invasion. Patients with elevated preoperative CA19-9 levels had lower 10-year survival than those without CA19-9 elevation. Multivariate analysis revealed that CA19-9 level, tumor grade, and tumor size are independent prognostic factors for long-term survival. In conclusion, a preoperative CA19-9 value >27 U/mL is associated with poor prognosis after resection for HCC.
据报道，肝细胞癌（HCC）患者的肿瘤标志物CA19-9血清水平会升高，但其临床病理意义仍不清楚。本研究纳入了304例接受HCC手术切除且有术前CA19-9数据的患者。血清CA19-9水平与临床病理因素相关。进行单因素和多因素分析以确定患者生存的预测因素。在受试者工作特征曲线分析中，CA19-9的截断值确定为27 U/mL。106例患者术前CA19-9值>27 U/mL。高血清CA19-9水平与患者年龄、性别、病毒状态、甲胎蛋白水平、肿瘤大小、肿瘤分级、肿瘤分期、肿瘤数量和血管侵犯无关。术前CA19-9水平升高的患者10年生存率低于未升高的患者。多因素分析显示，CA19-9水平、肿瘤分级和肿瘤大小是长期生存的独立预后因素。总之，术前CA19-9值>27 U/mL与HCC切除术后预后不良相关。
