铜催化的与过氧化物的有氧脂肪族 C-H 氧化。

Copper-catalyzed aerobic aliphatic C-H oxygenation with hydroperoxides.

机构信息

Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore. ; Tel: +65-65138013.

出版信息

Beilstein J Org Chem. 2013 Jun 25;9:1217-25. doi: 10.3762/bjoc.9.138. Print 2013.

DOI:10.3762/bjoc.9.138

PMID:23843917

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3701382/

Abstract

We report herein Cu-catalyzed aerobic oxygenation of aliphatic C-H bonds with hydroperoxides, which proceeds by 1,5-H radical shift of putative oxygen-centered radicals (O-radicals) derived from hydroperoxides followed by trapping of the resulting carbon-centered radicals with molecular oxygen.

摘要

我们在此报告了铜催化的脂肪族 C-H 键与过氧化物的有氧氧化反应，该反应通过过氧化物衍生的含氧中心自由基（O-自由基）的 1,5-H 自由基迁移进行，随后用分子氧捕获生成的碳中心自由基。