Díaz-Negrillo Antonio
Clinical Neurophysiology Unit, Infanta Elena Hospital, 28340 Valdemoro, Madrid, Spain.
Epilepsy Res Treat. 2013;2013:492524. doi: 10.1155/2013/492524. Epub 2013 Jun 12.
Sleep is probably one of the most important physiological factors implicated both in epileptic seizures and interictal epileptiform discharges. The neurophysiology concerning the relationship between sleep and epilepsy is well described in the literature; however, the pathological events that culminate in the seizures are poorly explored. The present paper intends to make a rigorous approach to the main mechanisms involved in this reciprocal relation. Knowledge of sleep and sleep deprivation effects in epilepsy stands as crucial in the understanding of how seizures are produced, their possible lines of treatment, and future research.
睡眠可能是与癫痫发作及发作间期癫痫样放电均相关的最重要的生理因素之一。文献中对睡眠与癫痫之间关系的神经生理学已有详尽描述；然而，导致癫痫发作的病理事件却鲜有深入探究。本文旨在对这种相互关系中涉及的主要机制进行严谨探讨。了解睡眠及睡眠剥夺对癫痫的影响，对于理解癫痫发作的产生机制、可能的治疗途径以及未来研究而言至关重要。
