组蛋白去乙酰化酶6的高选择性抑制剂的新合成——N-羟基-4-(2-甲基-1,2,3,4-四氢吡啶并[4,3b]吲哚-5-基甲基)苯甲酰胺——Tubastatin A
[New synthesis of highly selective inhibitor of histone deacetylase 6--N-hydroxy-4-(2-methyl-1,2,3,4-tetrahydro-pyrido[4,3b]indol-5-ylmethyl)benzamide--Tubastatin A].
作者信息
Kozlov M V, Kleĭmenova A A, Konduktorov K A, Kochetkov S N
出版信息
Bioorg Khim. 2013 Jan-Feb;39(1):117-20. doi: 10.1134/s1068162012060076.
PMID:23844513
Abstract
A four-stage synthesis of highly selective inhibitor of histone deacetylase 6--Tubastatin A was carried out. Convenient and safety reaction conditions were used throughout the synthesis.
摘要
进行了组蛋白脱乙酰酶6的高选择性抑制剂——Tubastatin A的四步合成。在整个合成过程中使用了方便且安全的反应条件。
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