1Charles University in Prague, Faculty of Pharmacy , Hradec Kralove , Czech Republic.
COPD. 2013 Oct;10(5):597-603. doi: 10.3109/15412555.2013.781151. Epub 2013 Jul 11.
Fat free mass index (FFMI) is an independent predictor of metabolic and functional consequences in COPD. For its measurement dual energy X-ray absorptiometry (DEXA), skin-fold anthropometry (SFA), bioelectrical impedance analysis (BIA) and bioimpedance spectroscopy (BIS) are used in clinical practice. The aim of our pilot study was to analyse precisely and critically which method is most accurate and available for common use in clinical practice for measurement of FFM by assessment against relevant DEXA in patients with COPD.
This was an observational cross-sectional study of consecutive COPD subjects. FFM by methods of SFA, two versions of BIA, and BIS was compared with that from clinically relevant DEXA in 41 outpatients (mean age 66.5 ± 7.7 yrs) with stable COPD, 34 men and 7 women, with mean BMI 28.2 ± 6.1 kg.m(-2).
All methods underestimate FFM in comparison with DEXA. In the general evaluation non-significant differences with the smallest mean bias were demonstrated for SFA (1.2 kg) and BIA (3.8 kg), but there was a difference of more than 9 kg using BIS and BIA COPD methods (p < 0.0001). The best agreement between DEXA and SFA was demonstrated via Lin's concordance coefficient and Bland-Altman test.
SFA has been demonstrated as an accurate, available and cheap method for determination of FFM and FM with application of the Durnin Womersley equation for body density and with the Siri equation for FM in patients with COPD. SFA can be easily applied in routine clinical practice.
无脂肪质量指数（FFMI）是 COPD 代谢和功能后果的独立预测因子。在临床实践中，使用双能 X 射线吸收法（DEXA）、皮褶人体测量法（SFA）、生物电阻抗分析（BIA）和生物阻抗谱（BIS）来测量 FFMI。我们的初步研究旨在精确地分析和批判性地评估哪种方法最准确且可在临床实践中常规用于通过与 COPD 患者的相关 DEXA 评估来测量 FFM。
这是一项连续 COPD 患者的观察性横断面研究。通过 SFA、两种 BIA 版本和 BIS 方法测量的 FFM 与 41 名稳定 COPD 门诊患者（平均年龄 66.5 ± 7.7 岁，34 名男性和 7 名女性，平均 BMI 28.2 ± 6.1 kg.m(-2)) 的临床相关 DEXA 进行了比较。
与 DEXA 相比，所有方法均低估了 FFM。在一般评估中，SFA（1.2 公斤）和 BIA（3.8 公斤）的平均偏差最小，无显著差异，但使用 BIS 和 BIA COPD 方法时，差异超过 9 公斤（p < 0.0001）。通过林氏一致性系数和 Bland-Altman 检验，显示 DEXA 和 SFA 之间的最佳一致性。
SFA 已被证明是一种准确、可用且廉价的方法，可用于确定 COPD 患者的 FFM 和 FM，应用 Durnin Womersley 方程确定体密度，应用 Siri 方程确定 FM。SFA 可在常规临床实践中轻松应用。
