Department of Endocrinology, First Hospital of Qinhuangdao, Qinhuangdao, Hebei 066000, China.
J Diabetes Complications. 2013 Sep-Oct;27(5):443-6. doi: 10.1016/j.jdiacomp.2013.06.001. Epub 2013 Jul 9.
To identify some risk factors of MCI among patients with type 2 diabetes(T2DM) and to find if there is any correlation between these factors and the degree of cognitive decline.
A total of 155 patients with T2DM referred to the Department of Endocrinology at First Hospital of Qinhuangdao were enrolled. To assess MCI the Montreal Cognitive Assessment (MoCA) scoring system was used. There were 66 patients with MCI and 89 patients without MCI (control). HbAlc, blood lipid, liver and renal functions were measured in all subjects.
Compared with the control group, type 2 diabetic patients with MCI had a longer duration of diabetes; higher non-high-density lipoprotein cholesterol (non-HDL-C), triglycerides, total cholesterol, HbA1c, and BMI; and lower high-density lipoprotein cholesterol (HDL-C) (P<0.05). The rates of patients with a history of habitual light-to-moderate alcohol consumption, a high proportion of Mediterranean-type diet, and regular physical activity were lower; and the rate of current smoking was higher in type 2 diabetic patients with MCI than the control group (P<0.05). Among patients with MCI, the results indicated that MoCA score was negatively correlated with non-HDL-C (r=-0.761 P<0.001).
Our results suggest that non-HDL-C can act as a readily available method for estimating risk of MCI in Chinese type 2 diabetic patient in routine clinical practice. Good lifestyle likely reduces MCI risk in diabetic patients.
确定 2 型糖尿病（T2DM）患者发生轻度认知障碍（MCI）的一些危险因素，并探讨这些因素与认知功能下降程度之间是否存在相关性。
选取秦皇岛市第一医院内分泌科就诊的 155 例 T2DM 患者，采用蒙特利尔认知评估量表（MoCA）评分系统评估 MCI，其中 MCI 患者 66 例，非 MCI 患者 89 例（对照组）。所有受试者均检测 HbAlc、血脂、肝肾功能。
与对照组相比，合并 MCI 的 T2DM 患者糖尿病病程较长，非高密度脂蛋白胆固醇（non-HDL-C）、三酰甘油、总胆固醇、糖化血红蛋白（HbA1c）、体质量指数（BMI）较高，高密度脂蛋白胆固醇（HDL-C）较低（P<0.05）；有习惯性轻中度饮酒史、地中海饮食比例高、经常进行体育锻炼的患者比例较低，有吸烟史的患者比例较高（P<0.05）。在 MCI 患者中，MoCA 评分与非-HDL-C 呈负相关（r=-0.761，P<0.001）。
非-HDL-C 可作为常规临床实践中评估中国 2 型糖尿病患者 MCI 风险的一种简便方法。良好的生活方式可能降低糖尿病患者 MCI 的发病风险。
