Department of Neurology, University Hospital Basel, Switzerland.
Mult Scler. 2014 Mar;20(3):322-30. doi: 10.1177/1352458513495583. Epub 2013 Jul 11.
Progenitor cells from the subventricular zone (SVZ) of the lateral ventricles are assumed to contribute to remyelination and resolution of black holes (BHs) in multiple sclerosis (MS). This process may depend on the distance between the lesion and the SVZ.
The objective of this paper is to investigate the relationship between lesion-to-ventricle (LV) distance and persistence of new BHs.
We analysed the magnetic resonance images (MRIs) of 289 relapsing-remitting (RR) MS patients, obtained during a multi-centre, placebo-controlled phase II trial over one year.
Overall, 112/289 patients showed 367 new BHs at the beginning of the trial. Of these, 225 were located in 94/112 patients at the level of the lateral ventricles on axial MRIs and included in this analysis. In total, 86/225 (38%) BHs persisted at month 12. LV distance in persistent BHs (PBHs) was not longer than in transient BHs. In fact PBHs tended to be closer to the SVZ than transient BHs. A generalised linear mixed multivariate model adjusted for BHs clustered within a patient and including patient- as well as lesion-specific factors revealed size, ring contrast enhancement, and shorter LV distance as independent predictors for BH persistence.
Location of BHs close to the lateral ventricles does not appear to favourably influence the resolution of new BHs in RRMS.
侧脑室室下区（SVZ）的祖细胞被认为有助于多发性硬化症（MS）中的髓鞘再生和黑洞（BH）的解决。这个过程可能取决于病变与 SVZ 之间的距离。
本文旨在研究病变与脑室（LV）之间的距离与新 BH 持续存在之间的关系。
我们分析了 289 例复发缓解型（RR）MS 患者的磁共振成像（MRI），这些患者在一年的多中心、安慰剂对照二期试验中获得。
总体而言，289 例患者中有 112 例在试验开始时出现 367 个新 BH。其中，225 个位于 94 例患者的侧脑室水平，位于轴位 MRI 上，包括在本次分析中。总共，86/225（38%）BH 在第 12 个月持续存在。在持续 BH（PBH）中，LV 距离并不长于瞬态 BH。事实上，PBH 比瞬态 BH 更接近 SVZ。调整了患者内聚类 BH 的广义线性混合多元模型，包括患者和病变特异性因素，显示大小、环对比增强和较短的 LV 距离是 BH 持续存在的独立预测因子。
BH 靠近侧脑室的位置似乎不利于 RRMS 中新 BH 的解决。
