Liu Yi, Li Peng, Hu Xiao, Hu Yu, Sun Hao-Gen, Ma Wei-Chao, Qiao Fei, He Min, You Chao
Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
J Int Med Res. 2013 Aug;41(4):1079-87. doi: 10.1177/0300060513487625. Epub 2013 Jul 11.
The relationship between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphisms and intracranial aneurysm (IA) has been studied in Caucasian and Japanese populations. The present study aimed to investigate this association in a Chinese population.
Patients with confirmed IA and age- and sex-matched control subjects without evidence of IA were enrolled. ACE I/D gene polymorphisms were analysed using polymerase chain reaction-restriction fragment length polymorphism.
A total of 220 patients with IA and 220 matched controls were enrolled. In the IA group, 64, 106 and 50 patients were of the II, ID and DD genotypes, respectively, compared with 44, 99 and 77 subjects in the control group. The ACE DD genotype and D allele frequencies were significantly lower in the IA group compared with the control group. There were no statistically significant differences in the site, shape, size and Fisher Grade of aneurysms between genotypes in patients with IA.
The ACE DD genotype may be a protective factor for IA in a Chinese population.
在白种人和日本人群中，已经对血管紧张素转换酶（ACE）插入/缺失（I/D）基因多态性与颅内动脉瘤（IA）之间的关系进行了研究。本研究旨在调查中国人群中的这种关联。
纳入确诊为IA的患者以及年龄和性别匹配、无IA证据的对照受试者。使用聚合酶链反应-限制性片段长度多态性分析ACE I/D基因多态性。
共纳入220例IA患者和220例匹配的对照。在IA组中，分别有64例、106例和50例患者为II、ID和DD基因型，而对照组中分别有44例、99例和77例受试者。与对照组相比，IA组中ACE DD基因型和D等位基因频率显著更低。IA患者不同基因型之间在动脉瘤的部位、形状、大小和Fisher分级方面无统计学显著差异。
ACE DD基因型可能是中国人群中IA的一个保护因素。
