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一名患有多发性骨髓瘤和继发性糖尿病的患者发生李斯特菌败血症并伴有中枢神经系统受累。

Listeria septicemia accompanied by central nervous system involvement in a patient with multiple myeloma and secondary diabetes.

作者信息

Hu Rong, Li Jia, Yao Kun, Miao Miao, Zhu Ke, Liu Zhuogang

机构信息

Department of Hematology, Shengjing Hospital, China Medical University, Shenyang,China.

出版信息

Am J Case Rep. 2013 Jul 1;14:226-9. doi: 10.12659/AJCR.889168. Print 2013.

DOI:10.12659/AJCR.889168
PMID:23847709
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3702689/
Abstract

PATIENT

Female, 58 FINAL DIAGNOSIS: Listeria septicemia Symptoms: Nausea • vomitting • high fever • apathetic intelligence • repeated convulsion

MEDICATION

Levofloxacin Clinical Procedure: - Specialty: Hematology Objective: Rare disease.

BACKGROUND

Multiple myeloma is a hematological malignancy that frequently causes secondary diabetes due to chemotherapy using hormones and infection due to immunosuppression.

CASE REPORTS

The patient was a 58-year-old woman with multiple myeloma and secondary diabetes complicated by listeria septicemia accompanied by central nervous system involvement. She initially received moxalactam and etimicin sulfate, but blood cultures detected Listeria monocytogenes. Levofloxacin was administered, but the symptoms did not improve. The patient ultimately died.

CONCLUSIONS

Listeria septicemia accompanied by central nervous system involvement in a patient with multiple myeloma and secondary diabetes is a relatively rare disease. Prevention, timely diagnosis, and treatment are the key steps for improvement. Blood glucose level control is another important factor that should be considered in the prevention and treatment for Listeria monocytogenes infection.

摘要

患者

女性,58岁 最终诊断:李斯特菌败血症 症状:恶心、呕吐、高热、智力迟钝、反复惊厥

用药

左氧氟沙星 临床程序:- 专业:血液学 目的:罕见疾病。

背景

多发性骨髓瘤是一种血液系统恶性肿瘤,常因使用激素化疗导致继发性糖尿病,并因免疫抑制引发感染。

病例报告

该患者为一名58岁女性,患有多发性骨髓瘤和继发性糖尿病,并发李斯特菌败血症并累及中枢神经系统。她最初接受了头孢氧哌唑和硫酸依替米星治疗,但血培养检测出单核细胞增生李斯特菌。给予左氧氟沙星治疗,但症状未改善。患者最终死亡。

结论

多发性骨髓瘤和继发性糖尿病患者并发累及中枢神经系统的李斯特菌败血症是一种相对罕见的疾病。预防、及时诊断和治疗是改善病情的关键步骤。血糖水平控制是预防和治疗单核细胞增生李斯特菌感染时应考虑的另一个重要因素。

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本文引用的文献

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Multiple myeloma.多发性骨髓瘤
Clin Cases Miner Bone Metab. 2012 Sep;9(3):150-2. Epub 2012 Dec 20.
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Entry of Listeria monocytogenes in mammalian epithelial cells: an updated view.单核细胞增生李斯特菌进入哺乳动物上皮细胞:更新的观点。
Cold Spring Harb Perspect Med. 2012 Nov 1;2(11):a010009. doi: 10.1101/cshperspect.a010009.
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Listeria monocytogenes brain abscess in a patient with multiple myeloma.一名多发性骨髓瘤患者发生单核细胞增生李斯特菌脑脓肿。
J Infect Dev Ctries. 2010 Dec 23;4(12):849-51. doi: 10.3855/jidc.898.
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Antibiotic treatment for bacterial meningitis caused by Listeria monocytogenes in a patient with multiple myeloma.利斯特菌性脑膜炎患者的抗生素治疗,该患者患有多发性骨髓瘤。
J Infect Chemother. 2010 Apr;16(2):123-5. doi: 10.1007/s10156-009-0014-3. Epub 2010 Jan 30.
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IL-23 is required for protection against systemic infection with Listeria monocytogenes.IL-23 对于抵抗李斯特菌全身性感染是必需的。
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Hyperglycemia in bacterial meningitis: a prospective cohort study.细菌性脑膜炎中的高血糖症:一项前瞻性队列研究。
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Listeria monocytogenes bacteremia in a twin pregnancy with differential outcome: fetus papyraceus and a full-term delivery.双胎妊娠李斯特菌败血症的不同结局:纸样胎儿和足月分娩
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Decreasing listeriosis mortality in the United States, 1990-2005.1990 - 2005年美国李斯特菌病死亡率的下降
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Sepsis and meningitis due to Listeria monocytogenes.由单核细胞增生李斯特菌引起的败血症和脑膜炎。
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Immune responses to Listeria monocytogenes.对单核细胞增生李斯特菌的免疫反应。
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