PML、SUMOylation 和衰老。
PML, SUMOylation, and Senescence.
机构信息
University Paris Diderot, Sorbonne Paris Cité, Hôpital St. Louis , Paris , France ; INSERM UMR 944, Equipe labellisée par la Ligue Nationale contre le Cancer, Institut Universitaire d'Hématologie, Hôpital St. Louis , Paris , France ; CNRS UMR 7212, Hôpital St. Louis , Paris , France.
出版信息
Front Oncol. 2013 Jul 4;3:171. doi: 10.3389/fonc.2013.00171. eCollection 2013.
Since its discovery, 25 years ago, promyelocytic leukemia (PML) has been an enigma. Implicated in the oncogenic PML/RARA fusion, forming elusive intranuclear domains, triggering cell death or senescence, controlled by and perhaps controlling SUMOylation… there are multiple PML-related issues. Here we review the reciprocal interactions between PML, senescence, and SUMOylation, notably in the context of cellular transformation.
自 25 年前发现以来，早幼粒细胞白血病（PML）一直是一个谜。它涉及致癌性 PML/RARA 融合，形成难以捉摸的核内域，触发细胞死亡或衰老，受 SUMO 化控制，并且可能控制着 SUMO 化……存在着多个与 PML 相关的问题。在这里，我们综述了 PML、衰老和 SUMO 化之间的相互作用，特别是在细胞转化的背景下。
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