Miyajima Risa, Kawazoe Hitoshi, Tsuneoka Kikue, Fujiwara Mitsuko, Kojima Yoh, Yakushijin Yoshihiro
Ambulatory Treatment Center, Ehime University Hospital.
Gan To Kagaku Ryoho. 2013 Apr;40(4):537-40.
Venous pain induced by oxaliplatin (L-OHP) is a clinical problem in relation to adherence in the CapeOX regimen. We investigated the preventive effect of nursing care preheating administration of L-OHP a hot compress for colorectal cancer patients who received L-OHP via the peripheral venous route between January 2010 and January 2011. L-OHP was diluted in 500 mL of 5% glucose and administered by 2 hours. We evaluated a total of 64 courses among fifteen patients. The presence of any symptoms, any pain with or without touch, and some symptoms of numbness at the L-OHP-administered arm were defined as phlebitis, venous pain, and acute peripheral neuropathy, respectively. The prevalence of phlebitis, venous pain, and acute peripheral neuropathy in the nursing care group was 56.5%, 32.6%, and 25.8%, respectively, which was not significantly less in comparison with the control group (72.2%, 38.9%, and 54.5%, respectively). These results suggest that both types of nursing care, preheating administration and a hot compress, may be effective for the relief of acute peripheral neuropathy induced by L-OHP.
奥沙利铂（L-OHP）引起的静脉疼痛是与CapeOX方案依从性相关的临床问题。我们调查了2010年1月至2011年1月期间通过外周静脉途径接受L-OHP治疗的结直肠癌患者，护理预热给药（L-OHP热敷）的预防效果。L-OHP用500 mL 5%葡萄糖稀释并在2小时内给药。我们对15例患者共评估了64个疗程。在给予L-OHP的手臂上出现任何症状、有或无触摸时的任何疼痛以及一些麻木症状，分别定义为静脉炎、静脉疼痛和急性周围神经病变。护理组静脉炎、静脉疼痛和急性周围神经病变的发生率分别为56.5%、32.6%和25.8%，与对照组（分别为72.2%、38.9%和54.5%）相比，差异无统计学意义。这些结果表明，护理预热给药和热敷这两种护理方式可能对缓解L-OHP引起的急性周围神经病变有效。
