Cloutier Frédéric-Charles, Rouleau Dominique M, Hébert-Davies Jonah, Beaumont Pierre H, Beaumont Eric
Centre de Recherche, Hôpital du Sacré-Coeur de Montréal and Département de Chirurgie, Université de Montréal , Montréal, Québec , Canada.
J Plast Surg Hand Surg. 2013 Dec;47(6):446-50. doi: 10.3109/2000656X.2013.778205. Epub 2013 Jul 15.
Nerve regeneration and functional recovery are often incomplete after peripheral neurotmetic lesion. Atorvastatin has been shown to be neuroprotective after transient ischaemia or traumatic injury. The aim of this study was to establish if systemic administration of Atorvastatin could improve functional muscle reinnervation after complete sciatic nerve section. Sixteen female Sprague-Dawley rats were used in this study. After a complete right sciatic nerve section, end-to-end microsuture repair was performed and fibrin glue was added. Three groups were studied: (1) sutures (S) + fibrin glue (F) only + saline administration for 14 days; (2) S+F+Atorvastatin administration for 14 days; and (3) uninjured nerve. Five months later, the sciatic nerve and the gastrocnemius muscle were isolated to perform in vivo electrophysiological measurements. Better kinematics was observed in atorvastatin-treated rats 5 months after its administration. Indeed, a larger excursion of the hip-ankle-toe angle during walking was observed. This effect was associated with the preservation of electromyographic activity (2.91 mV vs 0.77 mV) and maximal muscle force (85.1 g vs 28.6 g) on stimulation of the proximal nerve section. Five months after a neurotmetic lesion, the recovery is incomplete when using suture and fibrin glue only. Furthermore, the systemic administration of Atorvastatin for 14 days after lesion was beneficial in improving locomotion capability associated with the re-establishment of muscle strength and EMG activity.
周围神经断裂伤后，神经再生和功能恢复往往不完全。阿托伐他汀已被证明在短暂性缺血或创伤性损伤后具有神经保护作用。本研究的目的是确定全身给予阿托伐他汀是否能改善坐骨神经完全离断后的肌肉功能再支配。本研究使用了16只雌性Sprague-Dawley大鼠。在右侧坐骨神经完全离断后，进行端端显微缝合修复并添加纤维蛋白胶。研究分为三组：（1）仅缝合（S）+纤维蛋白胶（F）+给予生理盐水14天；（2）S+F+给予阿托伐他汀14天；（3）未损伤神经。五个月后，分离坐骨神经和腓肠肌进行体内电生理测量。给予阿托伐他汀治疗的大鼠在给药5个月后观察到更好的运动学表现。确实，在行走过程中观察到髋-踝-趾角有更大的摆动幅度。这种效应与刺激近端神经断端时肌电图活动的保留（2.91 mV对0.77 mV）和最大肌肉力量（85.1 g对28.6 g）相关。在神经断裂伤五个月后，仅使用缝合和纤维蛋白胶时恢复不完全。此外，损伤后全身给予阿托伐他汀14天有利于改善与肌肉力量和肌电图活动重建相关的运动能力。
