Pföhler Claudia, Knöpflen Tobias, Körner Rebecca, Vogt Thomas, Rösch Alexander, Müller Cornelia S L
Saarland University Hospital, Department of Dermatology, Homburg/Saar, Germany.
J Dtsch Dermatol Ges. 2013 Oct;11(10):993-9. doi: 10.1111/ddg.12121. Epub 2013 Jul 15.
The role of maspin has been discussed controversially in different tumors. In the majority of malignant tumors, maspin seems to act as a tumor suppressor. However, data about maspin expression as well as its function in melanoma are very inconsistent.
To investigate the expression of maspin in melanomas and to correlate the intensity of maspin staining with prognostic parameters of the tumor and with progression-free and overall survival.
Primary melanomas from 47 patients were investigated for maspin expression using immunohistochemistry.
Maspin was heterogeneously expressed predominantly in the cytoplasm of melanoma cells. Maspin staining intensity in the invasive part of the tumor correlated with parameters of prognosis such as Clark level (p = 0.05), tumor thickness (p = 0.002) and stage of disease (p = 0.023). Maspin staining intensity in the invasive front of the tumor significantly correlated with death from disease (p = 0.007) and shortened overall survival (p = 0.007).
In accordance with data concerning maspin expression in colorectal cancers, the expression of this protein in the invasive front of primary melanomas seems to correlate with local infiltration and tumor aggressiveness. Strong maspin expression in the invasive margin of primary melanomas therefore might reflect an aggressive tumor phenotype.
在不同肿瘤中，maspin的作用一直存在争议。在大多数恶性肿瘤中，maspin似乎起着肿瘤抑制因子的作用。然而，关于maspin在黑色素瘤中的表达及其功能的数据非常不一致。
研究maspin在黑色素瘤中的表达，并将maspin染色强度与肿瘤的预后参数、无进展生存期和总生存期相关联。
采用免疫组织化学法对47例患者的原发性黑色素瘤进行maspin表达检测。
maspin呈异质性表达，主要位于黑色素瘤细胞的细胞质中。肿瘤浸润部分的maspin染色强度与预后参数相关，如克拉克分级（p = 0.05）、肿瘤厚度（p = 0.002）和疾病分期（p = 0.023）。肿瘤浸润前沿的maspin染色强度与疾病死亡（p = 0.007）和总生存期缩短（p = 0.007）显著相关。
与结直肠癌中maspin表达的数据一致，该蛋白在原发性黑色素瘤浸润前沿的表达似乎与局部浸润和肿瘤侵袭性相关。因此，原发性黑色素瘤浸润边缘的maspin强表达可能反映了侵袭性肿瘤表型。
