有直接证据表明，一种γ-氨基丁酸模拟物通过中枢机制刺激胃酸分泌。

Direct evidence indicating that a GABA-mimetic stimulates acid secretion through central mechanisms.

作者信息

Hara N, Hara Y, Natsume Y, Goto Y

机构信息

Research Laboratories, Sumitomo Pharmaceuticals Co., Ltd., Osaka, Japan.

出版信息

Jpn J Pharmacol. 1990 Jun;53(2):271-4. doi: 10.1254/jjp.53.271.

DOI:10.1254/jjp.53.271

PMID:2385011

Abstract

Acid secretagogue effects of central and peripheral baclofen were compared in the rat. Intravenously (0.1-1.0 mg/kg) and intracerebroventricularly (0.1-1.0 micrograms) administered baclofen augmented acid output to the same degree in a dose-dependent manner. GABA microinjected into the lateral hypothalamus (200 and 400 micrograms) significantly increased acid output. These support the proposal that baclofen stimulates acid secretion through central mechanisms and also the possible role of GABA in central regulation mechanisms of acid secretion.

摘要

在大鼠中比较了中枢和外周巴氯芬的促酸分泌作用。静脉注射（0.1 - 1.0毫克/千克）和脑室内注射（0.1 - 1.0微克）巴氯芬均以剂量依赖性方式使酸分泌增加至相同程度。向外侧下丘脑微量注射γ-氨基丁酸（200和400微克）可显著增加酸分泌。这些结果支持了巴氯芬通过中枢机制刺激酸分泌的观点，以及γ-氨基丁酸在酸分泌中枢调节机制中可能发挥的作用。