Department of Urology, National Police Hospital, Seoul, Korea.
Urology. 2013 Sep;82(3):674-9. doi: 10.1016/j.urology.2013.03.047. Epub 2013 Jul 11.
To investigate the relationship between lower urinary tract symptoms (LUTS)/benign prostate hyperplasia (BPH) and a number of components of metabolic syndrome (MetS).
A total of 1224 male police officers aged 50-59 years who had participated in a health examination were included. LUTS/BPH were assessed by prostate-specific antigen, international prostate symptom score (IPSS), total prostate volume (TPV), maximum urinary flow rate (Qmax), and postvoid residual (PVR) urine volume. Testosterone levels were also examined. MetS was defined using National Cholesterol Education Program-Adult Treatment Panel III guidelines. The subjects were classified into 4 groups according to the number of exhibited MetS components (0, 1-2, 3, and 4-5). We used the Mantel-Haenszel extension test and logistic regression analyses.
MetS was diagnosed in 29.0% of the patients. The BPH ratio (IPSS >7, TPV ≥30 mL, and/or Qmax <15 mL/sec), TPV ≥30 mL, and PVR ≥50 mL significantly increased with an increasing number of metabolic abnormalities. The odds ratio (OR) in relation to a TPV ≥30 mL and a PVR ≥50 mL significantly rose as the number of positive MetS components increased after adjusting for age and testosterone. Additionally, the ORs (adjusting for age and testosterone) in relation to BPH also increased as the number of positive MetS components increased, with a suggestive threshold effect associated with 4-5 positive components (BPH: IPSS >7 + TPV ≥30 mL; 4 and 5 components, 3.496, 1.805-6.769, P = .001; BPH: IPSS >7 + TPV ≥30 mL + Qmax <15 mL/sec; 4 and 5 components, 5.458, 1.777-16.764, P = .002).
According to our results, the cases of LUTS/BPH were positively associated with the number of MetS components.
探讨下尿路症状（LUTS）/良性前列腺增生（BPH）与代谢综合征（MetS）多个成分之间的关系。
共纳入 1224 名 50-59 岁参加健康体检的男性警察。通过前列腺特异性抗原、国际前列腺症状评分（IPSS）、总前列腺体积（TPV）、最大尿流率（Qmax）和剩余尿量（PVR）评估 LUTS/BPH。同时检查睾酮水平。采用美国国家胆固醇教育计划成人治疗专家组 III 指南定义 MetS。根据表现出的 MetS 成分数量（0、1-2、3 和 4-5）将受试者分为 4 组。采用 Mantel-Haenszel 扩展检验和 logistic 回归分析。
29.0%的患者诊断为 MetS。BPH 发生率（IPSS>7、TPV≥30ml 和/或 Qmax<15ml/sec）、TPV≥30ml 和 PVR≥50ml 随代谢异常数量的增加而显著增加。校正年龄和睾酮后，与 TPV≥30ml 和 PVR≥50ml 相关的比值比（OR）随阳性 MetS 成分数量的增加而显著升高。此外，校正年龄和睾酮后，与 BPH 相关的 OR 随阳性 MetS 成分数量的增加而增加，与 4-5 个阳性成分呈提示性阈值效应（BPH：IPSS>7+TPV≥30ml；4 和 5 个成分，3.496，1.805-6.769，P=0.001；BPH：IPSS>7+TPV≥30ml+Qmax<15ml/sec；4 和 5 个成分，5.458，1.777-16.764，P=0.002）。
根据我们的结果，LUTS/BPH 病例与 MetS 成分数量呈正相关。
