Narama I, Kuroda J, Nagatani M, Miura K, Katoh T, Tsuchitani M
Hamamatsu Seigiken Research Laboratory, Co., Shizuoka, Japan.
Nihon Juigaku Zasshi. 1990 Jun;52(3):581-9. doi: 10.1292/jvms1939.52.581.
Stomach tissues from 222 beagle dogs, which were used for toxicological studies, were examined histopathologically. Out of 190 dogs fed the same diet, 185 had gastric lesions, whereas all of 32 dogs fed another diet were free from them. The gastric lesions were noted as an accumulation of eosinophils, infiltration of inflammatory cells including lymphocytes, plasma cells and histiocytes in the gastric lamina propria, formation of foreign body type multinucleated giant cells, focal desquamation and papillary proliferation of mucosal epithelium. The lesions were confined to the superficial layer of the antral and pyloric mucosa, and neither desmoplasia nor clinical signs were seen. Multinucleated giant cells often contained amphophilic foreign bodies of varying appearance with inconsistent reaction for periodic acid-Schiff (PAS), but no definite causal agents were detected.
对222只用于毒理学研究的比格犬的胃组织进行了组织病理学检查。在190只喂食相同饮食的狗中，185只出现胃部病变，而32只喂食另一种饮食的狗均未出现病变。胃部病变表现为嗜酸性粒细胞积聚、胃固有层中包括淋巴细胞、浆细胞和组织细胞在内的炎症细胞浸润、异物型多核巨细胞形成、黏膜上皮局灶性脱落和乳头样增生。病变局限于胃窦和幽门黏膜的表层，未见纤维组织增生和临床症状。多核巨细胞常含有外观各异的嗜两性异物，对过碘酸希夫（PAS）反应不一致，但未检测到明确的病原体。
