先前与心力衰竭相关的 CLCNKA 多态性（rs10927887；p.Arg83Gly）与 RENASTUR 队列中的估计肾小球滤过率有关。
A CLCNKA polymorphism (rs10927887; p.Arg83Gly) previously linked to heart failure is associated with the estimated glomerular filtration rate in the RENASTUR cohort.
机构信息
Genética Molecular-Laboratorio Medicina, HUCA, Oviedo, Spain.
出版信息
Gene. 2013 Sep 25;527(2):670-2. doi: 10.1016/j.gene.2013.06.055. Epub 2013 Jul 9.
A total of 569 individuals aged 55-85 and Caucasian were genotyped for SNP rs10927887 in the Ka renal chloride channel gene (CLCNKA). The following variables were significantly associated with an estimated glomerular filtration rate of (eGFR) <60 ml/min./1.73 m(2): age, type 2 diabetes, total cholesterol, LDL-cholesterol, and the CLCNKA GG genotype (p=0.03; OR=1.65, 95% CI=1.04-2.62). This novel finding could partly explain the reported greater risk of heart failure linked to the CLCNKA SNP, but requires confirmation on other populations.
共有 569 名年龄在 55-85 岁之间的白种人个体的 SNP rs10927887 被基因分型。以下变量与估计肾小球滤过率 (eGFR) <60 ml/min./1.73 m(2)显著相关：年龄、2 型糖尿病、总胆固醇、LDL-胆固醇和 CLCNKA GG 基因型 (p=0.03; OR=1.65, 95% CI=1.04-2.62)。这一新发现可以部分解释报道的 CLCNKA SNP 与心力衰竭风险增加有关，但需要在其他人群中得到证实。
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