IEEE Trans Biomed Circuits Syst. 2010 Dec;4(6):350-9. doi: 10.1109/TBCAS.2010.2081668.
This paper presents the implementation of a batteryless CMOS SoC with low voltage pulsed radio-frequency (PRF) stimulation. This implantable SoC uses 402 MHz command signals following the medical implanted communication system (MICS) standard and a low frequency (1 MHz) for RF power transmission. A body floating type rectifier achieves 84% voltage conversion ratio. A bi-phasic pulse train of 1.4 V and 500 kHz is delivered by a PRF driver circuit. The PRF parameters include pulse duration, pulse frequency and repetition rate, which are controllable via 402 MHz RF receiver. The minimal required 3 V RF Vin and 2.2 V VDDr is achieved at 18 mm gap. The SoC chip is fabricated in a 0.35 μm CMOS process and mounted on a PCB with a flexible spiral antenna. The packaged PRF SoC was implanted into rats for the animal study. Von Frey was applied to test the mechanical allodynia in a blinded manner. This work has successfully demonstrated that implanted CMOS SoC stimulating DRG with 1.4 V, 500 kHz PRF could significantly reduce spinal nerve ligation (SNL) induced mechanical allodynia for 3-7 days.
本文提出了一种无电池的 CMOS SoC 的实现，该 SoC 具有低压脉冲射频 (PRF) 刺激功能。这个可植入的 SoC 采用了 402MHz 的命令信号，符合医疗植入式通信系统 (MICS) 标准，并使用低频（1MHz）进行射频功率传输。一个体浮动式整流器实现了 84%的电压转换比。一个双相脉冲列车，由 PRF 驱动电路产生，其幅度为 1.4V，频率为 500kHz。PRF 参数包括脉冲持续时间、脉冲频率和重复率，这些参数可以通过 402MHz 的射频接收器进行控制。在 18mm 的间隙下，可实现最小要求的 3V RF Vin 和 2.2V VDDr。SoC 芯片采用 0.35μm CMOS 工艺制造，并安装在带有柔性螺旋天线的 PCB 上。封装好的 PRF SoC 已被植入大鼠进行动物研究。Von Frey 用于以盲法测试机械性痛觉过敏。这项工作成功地证明了，用 1.4V、500kHz 的 PRF 刺激背根神经节的植入式 CMOS SoC 可以显著减轻脊髓神经结扎 (SNL) 引起的机械性痛觉过敏，持续 3-7 天。
