Takami H, Shikata J, Horie H, Sekine K, Ito K
First Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan.
J Surg Oncol. 1990 Aug;44(4):205-7. doi: 10.1002/jso.2930440403.
The plasma level of PDN-21 was measured by RIA in 10 patients with medullary thyroid carcinoma (MTC). All 10 patients with MTC had extremely elevated PDN-21 levels. The correlations between PDN-21, calcitonin gene-related peptide, and calcitonin, (all of which are calcitonin gene products) were significant (P less than .001) in the 10 MTC patients. This study suggests that PDN-21, as well as calcitonin, may be a useful marker for the detection of patients with MTC.
采用放射免疫分析法测定了10例甲状腺髓样癌（MTC）患者血浆中PDN - 21的水平。所有10例MTC患者的PDN - 21水平均极度升高。在这10例MTC患者中，PDN - 21、降钙素基因相关肽和降钙素（所有这些都是降钙素基因产物）之间的相关性显著（P小于0.001）。本研究表明，PDN - 21以及降钙素可能是检测MTC患者的有用标志物。
