Oliveira Marina Reis, Martins Elisa das Graças, Célio-Mariano Ronaldo, Sonoda Celso Koogi, Rangel Garcia Idelmo, de Melo Willian Morais
Clinic & Surgery Department, Alfenas Dental School, Federal University of Alfenas-UNIFAL, Minas Gerais, Brazil.
J Craniofac Surg. 2013 Jul;24(4):e394-6. doi: 10.1097/SCS.0b013e3182802324.
Among the many tissues in the human body, bone has been considered as a powerful marker for regeneration and its formation serves as a prototype model for tissue engineering based on morphogenesis. Therefore, collagen type I is one of the most useful biomaterials used in tissue engineering as extracellular matrix components capable to promote bone healing. The literature reveals excellent biocompatibility and safety due to its biological characteristics, such as biodegradability and weak antigenicity, making collagen type I the primary resource in medical applications. Thus, it was also used for tissue engineering including skin replacement, bone substitutes, and artificial blood vessels and valves. The authors describe the treatment of an abscessed apical periodontal cyst and show good outcomes of bone healing, using tissue engineering, as collagen type I matrix.
在人体众多组织中，骨骼被视为再生的有力标志物，其形成作为基于形态发生的组织工程原型模型。因此，I型胶原蛋白是组织工程中最有用的生物材料之一，作为能够促进骨愈合的细胞外基质成分。文献显示，由于其生物特性，如可生物降解性和弱抗原性，I型胶原蛋白具有出色的生物相容性和安全性，使其成为医学应用的主要资源。因此，它也被用于包括皮肤替代、骨替代以及人造血管和瓣膜在内的组织工程。作者描述了使用组织工程，以I型胶原蛋白基质治疗根尖周脓肿囊肿，并展示了良好的骨愈合效果。
