Wu Zhihong, Ji Chunliang, Li Hui, Qiu Guixing, Gao Cunji, Weng Xisheng
Department of Orthopaedics, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
J Craniofac Surg. 2013 Jul;24(4):1252-6. doi: 10.1097/SCS.0b013e3182902dd3.
As a common disease, osteonecrosis attracts more and more attention. In this paper, we investigated the relationship between the alterations of endothelial-derived and platelet-derived microparticles and the changes of coagulation and inflammation in the steroid-induced avascular osteonecrosis of femoral head using the rabbit model. We also explored the possible mechanism of the membrane particles associated with the development of the rabbit femoral head ischemic necrosis. With a 28-day continuous observation, the level of membrane microparticles was significantly heightened after methylprednisolone treatment. The coagulating and inflammatory factors also tended to increase. The data demonstrated that the levels of membrane microparticles had significantly individual differences, which meant the increased levels of membrane microparticles may be related to hypercoagulability, thrombosis, and inflammation in microcirculation and played an important role in steroid-induced osteonecrosis. It will be very useful and helpful to guide clinical trials.
作为一种常见疾病，骨坏死越来越受到关注。在本文中，我们使用兔模型研究了内皮源性和血小板源性微粒的改变与类固醇诱导的股骨头缺血性坏死中凝血和炎症变化之间的关系。我们还探讨了与兔股骨头缺血性坏死发展相关的膜微粒的可能机制。经过28天的连续观察，甲基强的松龙治疗后膜微粒水平显著升高。凝血和炎症因子也有升高趋势。数据表明，膜微粒水平存在显著个体差异，这意味着膜微粒水平升高可能与微循环中的高凝性、血栓形成和炎症有关，并在类固醇诱导的骨坏死中起重要作用。这对于指导临床试验将非常有用且有帮助。
