1,8-Dinitropyrene: comparative mutagenicity in Chinese hamster V79 and CHO cells.
作者信息
O'Donovan M R
机构信息
Boots Pharmaceuticals Research Department, Nottingham, UK.
出版信息
Mutagenesis. 1990 May;5(3):275-7. doi: 10.1093/mutage/5.3.275.
PMID:2385180
Abstract
1,8-Dinitropyrene (1,8-DNP) was clearly mutagenic at the hprt locus in CHO cells, but not detectably mutagenic in V79 cells, following a 3-h treatment period. Preliminary data indicate that CHO, but not V79, cells have measurable levels of N-acetyltransferase activity, and this may contribute to the differential sensitivity of the two cell lines to the mutagenicity of 1,8-DNP.
摘要
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