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一种超灵敏的电化学适体传感器，具有自主组装的血红素-G-四链体 DNA zyme 纳米线，用于伪三重酶级联电化学催化放大。

An ultrasensitive electrochemical aptasensor with autonomous assembly of hemin-G-quadruplex DNAzyme nanowires for pseudo triple-enzyme cascade electrocatalytic amplification.

机构信息

Key Laboratory on Luminescence and Real-Time Analysis, Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.

出版信息

Chem Commun (Camb). 2013 Aug 25;49(66):7328-30. doi: 10.1039/c3cc42874e.

DOI:10.1039/c3cc42874e
PMID:23851915
Abstract

We for the first time fabricate a pseudo triple-enzyme cascade electrocatalytic electrochemical aptasensor by using the alcohol dehydrogenase (ADH) as well as the autonomously assembled hemin-G-quadruplex that simultaneously acted as an NADH oxidase and HRP-mimicking DNAzyme.

摘要

我们首次通过使用醇脱氢酶（ADH）以及自主组装的血红素-G-四链体来构建伪三重酶级联电化学生物传感器，血红素-G-四链体同时充当 NADH 氧化酶和 HRP 模拟 DNA 酶。

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