Neonatal Perinatal Medicine, Perinatal Institute, Cincinnati Children's Hospital Medical Center/University of Cincinnati, , Cincinnati, Ohio, USA.
Arch Dis Child Fetal Neonatal Ed. 2014 Mar;99(2):F166-8. doi: 10.1136/archdischild-2013-303999. Epub 2013 Jul 13.
To evaluate vitamin D (vitD) status in early preterm infants (EPTIs) at birth and during birth hospitalisation on current vitD intake.
DESIGN/METHODS: Serum 25-hydroxyvitamin-D [25(OH)D] concentrations, vitD intake and risk factors for low vitD status were assessed in 120 infants born at ≤32 weeks gestation.
Mean (SD) serum 25(OH)D at birth was 46.2 (14.0) nmol/L with lower concentrations in infants born <28 weeks than at 28-32 weeks gestation, p=0.02. Serum 25(OH)D was <50 nmol/L in 63% of mothers, 64% of infants at birth and 35% of infants at discharge. Mean daily vitD intake was 289±96 IU at 4 weeks of age and 60% achieved 400 IU/day intake at discharge.
Serum 25(OH)D <50 nmol/L was widespread in parturient women and in EPTIs at birth and at discharge. Optimising maternal vitD status during pregnancy and improving postnatal vitD intake may enhance infant vitD status during hospitalisation.
评估当前维生素 D（vitD）摄入量对出生时及住院期间极早产儿（EPTI）vitD 状态的影响。
方法/设计：本研究评估了 120 名胎龄≤32 周出生的婴儿的血清 25-羟维生素-D [25(OH)D] 浓度、vitD 摄入量和 vitD 状态低下的危险因素。
出生时平均（SD）血清 25(OH)D 为 46.2（14.0）nmol/L，<28 周出生的婴儿血清 25(OH)D 浓度低于 28-32 周出生的婴儿，p=0.02。63%的产妇、64%的出生时婴儿和 35%的出院时婴儿血清 25(OH)D<50 nmol/L。4 周龄时的平均每日 vitD 摄入量为 289±96IU，出院时 60%的婴儿达到 400IU/天的摄入量。
产妇和出生时及出院时的 EPTI 中，血清 25(OH)D<50 nmol/L 的情况较为普遍。优化孕妇孕期 vitD 状态并改善产后 vitD 摄入量可能会提高婴儿住院期间的 vitD 状态。
