George Renny Paul, Kumar Saravana, Ramakrishna T, Emmadi Pamela, Ambalavanan N
Department of Periodontics and Implantology, Meenakshi Ammal Dental College, Chennai, Tamil Nadu, India.
Indian J Dent Res. 2013 Jan-Feb;24(1):52-9. doi: 10.4103/0970-9290.114949.
The purpose of this study was to assess the clinical and microbiological effects of a newly developed root-conditioning gel system containing tetracycline and a mixture of tetracycline and citric acid on non-surgical periodontal therapy.
Four anterior teeth from four quadrants with a probing depth of 4-6 mm, in each of the 20 subjects with chronic periodontitis, were subjected to four different modalities of treatment. A total of 80 teeths were divided into four groups of 20 teeth each taken from separate quadrants, on the basis of one of the following four treatments: (1) Root planning alone in first quadrant (RP group); (2) tetracycline-containing gel in the second quadrant (TCG group); (3) root planning plus tetracycline-containing gel in third quadrant (RP + TCG group); (4) root planning plus a mixture of tetracycline and citric acid-containing gel in fourth quadrant (RP + TC-CAG group). Plaque index (PI), sulcular bleeding index, probing pocket depth, and clinical attachment level were measured for 0 day, 8 th week, and 12 th week, respectively. Subgingival plaque samples from each site were collected at the same visits and examined with dark field microscope for proportions of motile rods and spirochetes.
From 0 day to 12 th week, PI, sulcular bleeding index, probing pocket depth, and clinical attachment levels decreased significantly in all the groups. From 0 day to 12 th week, RP + TC-CAG group showed a significantly higher change in the PI score. From 0 day to 12 th week, RP group showed a significantly higher change in sulcular bleeding index score. A significant decrease in probing pocket depth and gain in clinical attachment level was noted at 12 th week in RP + TC-CAG group compared to the other groups. A significant decrease in the proportion of motile rods was found primarily in the RP + TC-CAG group. There was a decrease in the proportion of spirochetes in all the groups.
The results indicated that the use of a mixture of tetracycline and citric acid-containing gel was effective in improving gingival health and in changing subgingival microflora.
本研究旨在评估一种新开发的含四环素以及四环素与柠檬酸混合物的根面处理凝胶系统在非手术牙周治疗中的临床和微生物学效果。
在20名慢性牙周炎患者中，从四个象限选取四个前牙，探诊深度为4 - 6毫米，对这些牙齿进行四种不同的治疗方式。总共80颗牙齿根据以下四种治疗方式之一分为四组，每组20颗牙齿，分别取自不同象限：（1）第一象限仅进行根面平整（根面平整组）；（2）第二象限使用含四环素凝胶（含四环素凝胶组）；（3）第三象限进行根面平整加含四环素凝胶（根面平整 + 含四环素凝胶组）；（4）第四象限进行根面平整加含四环素与柠檬酸混合物的凝胶（根面平整 + 四环素 - 柠檬酸凝胶组）。分别在第0天、第8周和第12周测量菌斑指数（PI）、龈沟出血指数、探诊袋深度和临床附着水平。在相同就诊时从每个部位收集龈下菌斑样本，并用暗视野显微镜检查活动杆菌和螺旋体的比例。
从第0天到第12周，所有组的PI、龈沟出血指数、探诊袋深度和临床附着水平均显著下降。从第0天到第12周，根面平整 + 四环素 - 柠檬酸凝胶组的PI评分变化显著更高。从第0天到第12周，根面平整组的龈沟出血指数评分变化显著更高。与其他组相比，根面平整 + 四环素 - 柠檬酸凝胶组在第12周时探诊袋深度显著降低，临床附着水平显著增加。活动杆菌比例的显著降低主要出现在根面平整 + 四环素 - 柠檬酸凝胶组。所有组中螺旋体比例均有所下降。
结果表明，使用含四环素与柠檬酸混合物的凝胶在改善牙龈健康和改变龈下微生物群方面是有效的。
