Department of Biological Science, The Florida State University, Tallahassee, FL 32306, USA.
Viruses. 2013 Jul 11;5(7):1684-701. doi: 10.3390/v5071684.
Cyclophilins are peptidyl-prolyl cis/trans isomerases important in the proper folding of certain proteins. Mounting evidence supports varied roles of cyclophilins, either positive or negative, in the life cycles of diverse viruses, but the nature and mechanisms of these roles are yet to be defined. The potential for cyclophilins to serve as a drug target for antiviral therapy is evidenced by the success of non-immunosuppressive cyclophilin inhibitors (CPIs), including Alisporivir, in clinical trials targeting hepatitis C virus infection. In addition, as cyclophilins are implicated in the predisposition to, or severity of, various diseases, the ability to specifically and effectively modulate their function will prove increasingly useful for disease intervention. In this review, we will summarize the evidence of cyclophilins as key mediators of viral infection and prospective drug targets.
亲环素是参与某些蛋白质正确折叠的肽基脯氨酰顺/反式异构酶。越来越多的证据表明，亲环素在多种病毒的生命周期中发挥着不同的作用，无论是积极的还是消极的，但这些作用的性质和机制尚待确定。亲环素作为抗病毒治疗药物靶点的潜力已被非免疫抑制性亲环素抑制剂（CPIs）所证明，包括在临床试验中针对丙型肝炎病毒感染的 Alisporivir。此外，由于亲环素与各种疾病的易感性或严重程度有关，因此能够特异性和有效地调节其功能将对疾病干预越来越有用。在这篇综述中，我们将总结亲环素作为病毒感染关键介质和有前途的药物靶点的证据。
