The School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, 4072, Australia.
Cell Mol Neurobiol. 2013 Oct;33(7):867-73. doi: 10.1007/s10571-013-9961-4. Epub 2013 Jul 14.
The transcription factor nuclear factor one X (NFIX) plays a central role during the development of the neocortex and hippocampus, through the activation of astrocyte-specific gene expression and the repression of progenitor-specific pathways. However, our understanding of transcriptional targets of NFIX during cortical development remains limited. Here, we identify the transcription factor Bobby sox (Bbx) as a target for NFI-mediated transcriptional control. BBX is expressed within ventricular zone progenitor cells within the developing neocortex and hippocampus, and its expression is upregulated in Nfix (-/-) mice. Moreover, we reveal that NFIX can repress Bbx promoter-driven expression. Collectively, these data suggest that Bbx is a downstream target of NFIX during development of the forebrain.
转录因子核因子一 X (NFIX) 在大脑皮层和海马体的发育过程中发挥核心作用，通过激活星形胶质细胞特异性基因表达和抑制祖细胞特异性途径。然而，我们对 NFIX 在皮质发育过程中的转录靶标仍知之甚少。在这里，我们确定转录因子 Bobby sox (Bbx) 为 NFI 介导的转录控制的靶标。BBX 在发育中的大脑皮层和海马体的脑室区祖细胞中表达，并在 Nfix(-/-) 小鼠中上调表达。此外，我们揭示 NFIX 可以抑制 Bbx 启动子驱动的表达。总的来说，这些数据表明 Bbx 是 NFIX 在大脑前脑发育过程中的下游靶标。
